Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke

NCT07069452 | Recruiting

• 1 other identifier: 0111_NEUROLOGIE
• Study Type: observational
• Target: 152
• Locations: 1 country
• Sites: 1

Brief Summary

This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot. Even with these treatments, about half of patients don't fully recover. The study aims to see if certain brain imaging scores, especially when combined, can better predict how well patients will recover 90 days after their stroke and if their blood vessels reopen successfully. The study will include 152 patients and last about 9 months. The goal is to find easy and reliable tools that doctors can use to make better treatment decisions.

Conditions

Stroke, Ischemic; Thrombectomy; Thrombolytic Therapy; Brain Ischemia; Prognosis; Magnetic Resonance Imaging; Outcome Assessment (Health Care)

Outcome Measures

Primary Outcomes (1)

• Favorable functional outcome defined as a mRS score of 0 to 2 at 90 days

  90 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients (aged 18 and over) who have experienced an acute ischemic stroke confirmed by imaging. These patients have undergone combined treatment with thrombolysis (clot-busting medication) and thrombectomy (mechanical clot removal). They are selected from a single medical center where detailed clinical and imaging follow-up data, including functional outcomes at 90 days, are available. Participants must have adequate-quality imaging and not have experienced early death or loss to follow-up before evaluation.

You may qualify if:

• Patients aged 18 years or older
• Confirmed acute ischemic stroke on imaging
• Treated with both thrombolysis and thrombectomy
• Clinical follow-up data available at 90 days (mRS score)

You may not qualify if:

• Primary hemorrhagic stroke
• Early death or loss to follow-up without evaluation
• Poor-quality imaging that cannot be analyzed

Sponsors & Collaborators

• Centre Hospitalier de Gonesse: lead

Study Sites (1)

Centre Hospitalier de Gonesse

Gonesse, France

RECRUITING

MeSH Terms

Conditions

Ischemic Stroke; Brain Ischemia

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2025
• First Posted: July 16, 2025
• Study Start: April 15, 2025
• Primary Completion: January 15, 2026
• Study Completion: January 15, 2026
• Last Updated: July 16, 2025

Record last verified: 2025-07

Locations

FR (1)