Implementation of New Multimodal MRI Sequences by Fingerprint to Improve Ischemic Stroke Examination.

NCT07199920 | Not Yet Recruiting

• 1 other identifier: 38RC23.0410
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Currently, standard brain MRI takes 20 to 25 minutes, but in the case of ischemic stroke, every minute counts to limit the extension of the necrotic core, with the possibility of recanalizing the occluded artery (intravenous thrombolysis and/or mechanical thrombectomy). The recent concept of MRI "Fingerprint" (Magnetic Resonance Fingerprinting, MRF) allows the production of a rapid single sequence and the extraction of numerous parameters. Demonstrating the feasibility and interpretability of multimodal MRI images acquired in MRF would make it possible to consider implementing and, ultimately, replacing conventional sequences, with the aim of shortening acute stroke management times, increasing the number of sequences acquired within a short timeframe (by increasing informativeness), and thus improving patients\' short and long-term vital and functional prognosis.

Conditions

Stroke, Ischemic

Keywords

MRF (Magnetic Resonance Fingerprinting); stroke; MRI

Outcome Measures

Primary Outcomes (1)

• Success rate and interpretability of images acquired in MRF

  Assessment of the success rate and interpretability (subjective evaluation with Likert scales of very satisfactory, satisfactory, insufficient, or unacceptable)

  From enrollment to the end of the MRI exam

Secondary Outcomes (1)

• Characterize and extract the physical parameters of the signal acquired with MRF.

  From enrollment to the end of the MRI exam

Study Arms (1)

Experimental

EXPERIMENTAL

Every patient will perform classic brain MRI with additional MRF sequences.

Device: Achieva 3.0T dStream Philips

Interventions

Achieva 3.0T dStream Philips DEVICE

Classic and MRF sequences will be carried out on the clinical machine (Achieva 3.0T dStream Philips) of the IRMaGe platform (CHUGA, Université Grenoble Alpes, Inserm, CNRS).

Experimental

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \> 18 years
• Subacute ischemic stroke patients (\< 15 days after onset)
• Middle cerebral artery or anterior cerebral artery territory stroke
• Modified Rankin Scale (mRS) = 0-4

You may not qualify if:

• \* MRI contraindications

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• Grenoble Institut des Neurosciences: collaborator

Study Sites (1)

Chu Grenoble Alpes

Grenoble, 38043, France

Location

MeSH Terms

Conditions

Ischemic Stroke; Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Loïc LEGRIS, Dr

  llegris@chu-grenoble.fr

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zaza Putkaradze, Dr

CONTACT

0476767842; zputkaradze@chu-grenoble.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2024
• First Posted: September 30, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: September 30, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)