The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation

NCT07067879 | Recruiting

• 1 other identifier: HREC-DCU2025-037
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the efficacy of the novel lip product containing Caulerpa lentillifera extract on the appearance and perception of dark lips in Thai adults aged 18 to 60 who report concerns about darkened lips. The main question it aims to answer is: Can the novel lip product containing C. lentillifera extract will significantly improve the appearance and perception of dark lips in Thai adults by reducing hyperpigmentation compared to baseline measurements? Participants will apply the lip product twice a day, in the morning after breakfast and before bedtime, and refrain from using other lip products throughout the clinical trial period (7 days). Researchers will compare the result to baseline measurements

Conditions

Hyperpigmentation

Keywords

Lip hyperpigmentation; Seaweed; Antera3D; Lip care

Outcome Measures

Primary Outcomes (1)

• Change from baseline in improving lip hyperpigmentation

  Lip hyperpigmentation is assessed using Antera3D at baseline and 7 day after usage

  Baseline and 7 days

Secondary Outcomes (2)

• Change from baseline in improving lip dryness

  Baseline and 7 days

• Subjective assessment by participants

  Baseline, day 1, and day 7

Study Arms (1)

Lip product application group

EXPERIMENTAL

Other: Lip product

Interventions

Lip product OTHER

Lip product containing Caulerpa lentillifera extract

Lip product application group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Understand the study protocol and provide informed consent after being informed of potential risks and benefits.
• Refrain from using any other lip products, including lipstick, lip gloss, or lip conditioners, during the study period.

You may not qualify if:

• Have a known allergy or sensitivity to cosmetic products or Caulerpa lentillifera.
• Are on medication one month prior to study commencement.
• Exhibit lip abnormalities such as malformation, inflammation, swelling, or sores.

Sponsors & Collaborators

• Chulalongkorn University: lead

Study Sites (1)

Faculty of dentistry, Chulalongkorn university

Bangkok, 10330, Thailand

RECRUITING

MeSH Terms

Conditions

Hyperpigmentation

Condition Hierarchy (Ancestors)

Pigmentation Disorders; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2025
• First Posted: July 16, 2025
• Study Start: July 23, 2025
• Primary Completion: August 13, 2025
• Study Completion: August 13, 2025
• Last Updated: July 16, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)