Adaptive Cell Phone Support (ACPS)
ACPS
Adaptive Cell Phone Support to Promote Medication Adherence Among Adolescents and Young Adults With Chronic Health Conditions
1 other identifier
interventional
96
1 country
1
Brief Summary
The goal of this pilot clinical trial is to test a mobile health intervention for promoting medication adherence in a population of adolescents and young adults with chronic health conditions. The main question it aims to answer is:
- Is an adaptive intervention (personalizing the intensity of support based on patients' needs) efficacious for promoting medication adherence Researchers will compare the adaptive intervention to automated text message reminders see if the adaptive intervention shows stronger positive effects on medication adherence.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2027
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 7, 2025
CompletedFirst Posted
Study publicly available on registry
July 15, 2025
CompletedStudy Start
First participant enrolled
August 1, 2027
ExpectedPrimary Completion
Last participant's last visit for primary outcome
July 30, 2029
Study Completion
Last participant's last visit for all outcomes
July 30, 2030
July 30, 2025
July 1, 2025
2 years
July 7, 2025
July 28, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Mean scores on the Mobile Health App Usability Questionnaire
Higher scores indicate greater ease with which users can use technology to achieve a particular goal; the minimum value of this questionnaire is 1 and the maximum value is 7.
Baseline to 12 weeks
Total scores on the theoretical framework of acceptability questionnaire
Higher scores indicate a greater "extent to which people delivering or receiving a healthcare intervention consider it to be appropriate, based on anticipated or experienced cognitive and emotional responses to the intervention"; the minimum value of this questionnaire is 7 and the maximum value is 35.
Baseline to 12 weeks
Total scores on the Visual Analogue Scale
Percentage of doses taken our of 100%; higher numbers indicate greater medication adherence. This scale presents participants with a line, marked 0 on the left and 100 on the right, and participants can drag a marker to the place on the line that best visually indicated their adherence.
Baseline to 12 weeks
Total scores on Rollnick's Readiness Ruler
Higher scores on this measure indicate more motivation to take medication as prescribed; the minimum value of this questionnaire is 0 and the maximum value is 10.
Baseline to 12 weeks
Total Transition Readiness scores on the Successful Transition to Adulthood with Therapeutic = Rx Questionnaire
Higher scores on extent to which patients are prepared to manage their health condition as adults, outside of the pediatric system; ; the minimum value of this questionnaire is 0 and the maximum value is 90.
Baseline to 12 weeks
Study Arms (3)
Adaptive Cell Phone Support
EXPERIMENTALComputer-delivered cell phone support (reminders, problem-solving, referrals to resources) and responsive human coaching (phone calls, test messages, in-app messaging) to improve medication adherence.
Computer-Delivered Cell Phone Support
EXPERIMENTALComputer-delivered cell phone support (reminders, problem-solving, referrals to resources)
Automated Text Reminders
ACTIVE COMPARATORScheduled one-way text automated message reminders to take medication
Interventions
Mobile health adherence promotion based on the supportive accountability model
Mobile health adherence promotion based on the supportive accountability model
Scheduled text reminder to take medication
Eligibility Criteria
You may qualify if:
- Children's Hospital Los Angeles patient
- between 15-20 years old
- taking at least one oral medication per day for a chronic health condition
- English speaking
- demonstrating sufficient cognitive capacity to engage in the assent/consent process and study procedures
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Children Hospital Los Angeles
Los Angeles, California, 90027, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Caitlin Sayegh, PhD
Children's Hospital Los Angeles
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SEQUENTIAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor of Clinical Pediatrics
Study Record Dates
First Submitted
July 7, 2025
First Posted
July 15, 2025
Study Start (Estimated)
August 1, 2027
Primary Completion (Estimated)
July 30, 2029
Study Completion (Estimated)
July 30, 2030
Last Updated
July 30, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will share
- Time Frame
- Final submission and release of the study data will occur no later than the time of an associated publication or the end of the performance period, whichever comes first. Study data deposited in DASH will be available to the research community in perpetuity.
- Access Criteria
- https://dash.nichd.nih.gov/resource/DASHUserAgreement
The data will include electronically-administered survey items assessing demographic characteristics, intervention usability, intervention acceptability, medication adherence, motivation for adherence, transition readiness skills, and allocation of treatment responsibility as well as medication regimen complexity data and pharmacy possession refill rates abstracted from the electronic medical chart, and behavioral engagement data collected via the Computerized Intervention Authoring Software.