Phenotyping Adherence Through Technology-Enabled Reports and Navigation

NCT05766423 | Completed Results

• 2 other identifiers: STU00217555P30AG059988
• Study Type: interventional
• Target: 73
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being conducted to adapt and pilot test a technology-enabled, primary care strategy for routinely monitoring medication use and adherence among older adults with multiple chronic conditions and polypharmacy.

Conditions

Medication Adherence

Outcome Measures

Primary Outcomes (1)

• Medication Adherence

  Participants' medication adherence will be measured at about 2-4 weeks after their clinic visit using a validated self-report measure: ASK-12. The 12-item measure assesses general medication attitudes and beliefs across three domains: 1) inconvenience/forgetfulness, 2) treatment beliefs, and 3) behaviors. Response options range from "Strongly Disagree" to "Strongly Agree". Scores can range from 12-60 with higher scores representing greater barriers to adherence.

  About 2-4 Weeks

Secondary Outcomes (1)

• Fidelity

  By the scheduled clinic visit (baseline)

Study Arms (2)

Usual Care

NO INTERVENTION

Usual care includes: 1. The normal standard clinical practices at the participating practice. 2. No specific materials to promote PATTERN, and no additional materials that include adherence assessments or care alert notifications.

The PATTERN Intervention

ACTIVE COMPARATOR

The intervention components include: 1. An adherence assessment completed by participants ahead of a regularly scheduled clinic visit. 2. Care alert notifications directed to a nurse pool and/or member of the clinical care team.

Behavioral: The PATTERN Intervention

Interventions

The PATTERN Intervention BEHAVIORAL

The intervention components include: 1. An adherence assessment that requests patients to self-report via MyChart about their medication use. The assessment provides a link between the health center and the patient ahead of a regularly scheduled clinic visit. 2. Care alert notifications directed to a nurse pool and/or member of the clinical care team when a medication adherence related problem is identified by the adherence assessment. The alert will also include the type of problem the patient is experiencing (cognitive, psychological, medical, regiment, social and/or economic). Once they receive these alerts, the care team can then activate appropriate staff and/or resources to respond.

The PATTERN Intervention

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Each participant must:
• Be an adult aged 65 or older
• Speak English as their primary language
• Have multiple chronic conditions
• Be prescribed 8 or more medications
• Be primarily responsible for administering own medication
• Receive medical care at the participating primary care practice
• Have access to the internet and an active email address
• Be signed up for the patient portal (MyChart)

You may not qualify if:

• No participant can:
• Have severe, uncorrectable visual, hearing or cognitive impairments that would preclude study consent or participation

Sponsors & Collaborators

• The Claude D. Pepper Older Americans Independence Centers: collaborator
• Northwestern University: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Northwestern University

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Medication Adherence

Condition Hierarchy (Ancestors)

Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Results Point of Contact

• Title: Research Assistant Professor
• Organization: Northwestern University

allison.pack@northwestern.edu

312-503-0274

Study Officials

• Allison Pack, PhD, MPH

  Northwestern University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 17, 2023
• First Posted: March 13, 2023
• Study Start: January 18, 2024
• Primary Completion: August 15, 2024
• Study Completion: August 15, 2024
• Last Updated: June 11, 2025
• Results First Posted: June 11, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)