NCT07064044

Brief Summary

Patellofemoral pain syndrome (PFPS) is one of the most commonly diagnosed conditions among adolescents and adults with knee complaints, accounting for approximately 25% of knee disorders diagnosed in sports medical clinics. While the etiology of PFPS is suggested to be multifactorial, several contributing factors such as lower knee extensors strength, quadriceps imbalance, weak hip abductors and overuse have been identified.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2025

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

July 3, 2025

Completed
11 days until next milestone

First Posted

Study publicly available on registry

July 14, 2025

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2025

Completed
Last Updated

July 14, 2025

Status Verified

July 1, 2025

Enrollment Period

3 months

First QC Date

July 3, 2025

Last Update Submit

July 3, 2025

Conditions

Keywords

PainDisabilityRange of motion

Outcome Measures

Primary Outcomes (3)

  • Numerical Pain Rating Scale (NPRS)

    The Numeric Pain Rating Scale (NPRS) is perhaps the most frequently applied scale used to quantify pain intensity in the clinical setting. It is an 11-point numeric scale, ranging from 0 indicating no pain to 10 indicating worst pain imaginable

    upto 4 weeks

  • Universal Goniometer

    Universal goniometer (UG) is commonly used as a standard method to evaluate range of motion (ROM) as part of joint motions.

    upto 4 weeks

  • Kujala Anterior Knee Pain Scale (AKPS)

    The Kujala patellofemoral scoring system is a tool used to assess the functional ability of the knee joint, specifically in relation to patellofemoral-related issues. This scoring system ranges from 0 to 100, with higher scores indicating better knee function and less pain, while lower scores indicate greater dysfunction and more severe pain.

    upto 4 weeks

Study Arms (2)

Muscle Energy Technique and Patellar Inferior Glide

EXPERIMENTAL

Muscle Energy Technique for Hamstrings and Quadriceps While the patient contract muscle (Hamstring / Quadriceps) the therapist applies a gentle controlled force. After the contraction patient release and the therapist reposition the leg into a new barrier. Intensity of contraction will be 20-25-% of maximum strength. Each contraction will be held for 5-7 seconds, followed by additional passive stretching maintained for 30 and the relaxation patellar inferior glide applied at patella: the examiner applied a gentle downward force on the patella with their right hand, while the left hand controlled the direction of the patella's movement. This will be applied for 3-4 minutes as tolerated by the patient.

Other: Muscle Energy Technique and Patellar Inferior Glide

Conventional Physiotherapy treatment

ACTIVE COMPARATOR

TENS applied, Ultrasound therapeutic modality applied, Hip and knee muscles strengthening exercises

Other: Conventional Traetment

Interventions

TENS applied for 10 minutes, Therapeutic ultrasound,Hip abductors and lateral rotators strengthening, Hamstring muscle passive stretching, Isometrics for quadriceps, given thrice a week for 4 weeks .

Conventional Physiotherapy treatment

Muscle Energy Technique for Hamstrings and Quadriceps While the patient contract muscle (Hamstring / Quadriceps) the therapist applies a gentle controlled force. After the contraction patient release and the therapist reposition the leg into a new barrier. Intensity of contraction will be 20-25-% of maximum strength. Each contraction will be held for 5-7 seconds, followed by additional passive stretching maintained for 30 and the relaxation patellar inferior glide applied at patella: the examiner applied a gentle downward force on the patella with their right hand, while the left hand controlled the direction of the patella's movement. This will be applied for 3-4 minutes as tolerated by the patient.

Muscle Energy Technique and Patellar Inferior Glide

Eligibility Criteria

Age20 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Individuals with age 20-40Years
  • Pain rating \> 3 and \< 7 on NPRS
  • Patella alta confirmed with ISI (Insall Salvati index) ratio \> 1.2 on lateral knee radiograph
  • Positive Ely's test for rectus femoris tightness
  • Positive eccentric step test

You may not qualify if:

  • History of patellofemoral dislocation
  • Knee osteoarthritis
  • Recently undergo to surgery to knee
  • Fracture in knee region
  • Positive patellar tap test for knee joint effusion
  • Lateral and medial tracking of patella
  • Patients taking NSAIDs and corticosteroids

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rims Rehabilitation Centre

Multan Khurd, Punjab Province, 54000, Pakistan

Location

Related Publications (6)

  • Widhiantari NKE, Widnyana M, Jawi IM. Risk factors of the patellofemoral pain syndrome. Kinesiology and Physiotherapy Comprehensive. 2023;2(3):74-80.

    BACKGROUND
  • Leon-Morillas F, Garcia-Marin M, Corujo-Hernandez C, Martin Aleman M, Castellote-Caballero Y, Cahalin LP, Infante-Guedes A, Cruz-Diaz D. Evaluating the Impact of Flossing Band Integration in Conventional Physiotherapy for Patellofemoral Pain Syndrome. J Clin Med. 2024 May 17;13(10):2958. doi: 10.3390/jcm13102958.

    PMID: 38792499BACKGROUND
  • Abd Elhady AM, Abd Elmajeed SF, Abd Allah WA, Abd Elhamed HB. Knee Alignment-Oriented Balance Exercises Versus Conventional Balance Exercises in Treating Patellofemoral Pain Syndrome. The Egyptian Journal of Hospital Medicine (January 2024).94:975-81.

    BACKGROUND
  • Raju A, Jayaraman K, Nuhmani S, Sebastian S, Khan M, Alghadir AH. Effects of hip abductor with external rotator strengthening versus proprioceptive training on pain and functions in patients with patellofemoral pain syndrome: A randomized controlled trial. Medicine (Baltimore). 2024 Feb 16;103(7):e37102. doi: 10.1097/MD.0000000000037102.

    PMID: 38363950BACKGROUND
  • Mv VK, Subramanian NB, S S, Kotamraju S, Krishnan M. Physiotherapeutic interventions on quadriceps muscle architecture in patello-femoral pain syndrome. Bioinformation. 2023 Apr 30;19(4):454-459. doi: 10.6026/97320630019454. eCollection 2023.

    PMID: 37822824BACKGROUND
  • Veeresh G, Kumar SS, Sasidharan S. MANUAL THERAPY FOR PATELLOFEMORAL PAIN SYNDROME REVIEW OF LITERATURE. EPRA International Journal of Multidisciplinary Research (IJMR). 2024;10(5):298-309.

    BACKGROUND

MeSH Terms

Conditions

Patellofemoral Pain SyndromePain

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Samrood Akram, PhD*

    Riphah International University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Samrood Akram, PhD Scholar

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 3, 2025

First Posted

July 14, 2025

Study Start

July 1, 2025

Primary Completion

October 1, 2025

Study Completion

October 1, 2025

Last Updated

July 14, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations