Osteoporosis After Stroke

NCT07059468 | Completed DMC

• 2 other identifiers: E-34225015 06/001Gaziler
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the clinical features affecting bone mineral density in plegic and non-plegic extremities in hemiplegic patients with stroke in the subacute and chronic phases.

Conditions

Stroke; Osteoporosis

Keywords

Stroke Osteoporosis

Outcome Measures

Primary Outcomes (1)

• Dual X-ray absorptiometry (DXA)

  Bone mineral density/ Bone mineral density (BMD) will be measured on the lumbar spine (L1-L4) and femoral neck by dual X-ray absorptiometry (DXA) method./ Baseline

  baseline

Secondary Outcomes (7)

• Manual muscle strength measurement/ Muscle strength

  baseline

• Fugl-Meyer Lower Extremity Motor Subscale

  baseline

• Functional Ambulation Classification

  baseline

• Spasticity assessment/ Ashworth graded spasticity from 0 to 4

  baseline

• Berg Balance Scale

  baseline

Interventions

Bone mineral density/ Bone mineral density (BMD) will be measured on the lumbar spine (L1-L4) and femoral neck by dual X-ray absorptiometry (DXA) DIAGNOSTIC_TEST

Bone mineral density/ Bone mineral density (BMD) will be measured on the lumbar spine (L1-L4) and femoral neck by dual X-ray absorptiometry (DXA) method

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

44 Patients aged 40-65 years with a unilateral stroke confirmed by magnetic resonance imaging (MRI) or computed tomography (CT)

You may qualify if:

• Patients aged 40-65 years with a unilateral stroke confirmed by magnetic resonance imaging (MRI) or computed tomography (CT)
• Patients with a cognitive status sufficient to understand the study instructions (Mini-Mental State Assessment score ≥ 23)
• Patients with stable medical and psychological status
• Patients willing to participate in the study

You may not qualify if:

• Presence of hip pathologies that may lead to incorrect measurements in bone mineral density (advanced osteophytic coxarthrosis, heterotrophic ossification, internal fixator, etc.)
• Previous hip, lumbar vertebra fractures (osteoporotic compression fractures)
• History of multiple strokes
• History of concomitant neurological diseases other than stroke (Parkinson, multiple sclerosis, myopathy, etc.)
• History of diseases that may cause secondary osteoporosis (hypogonadism, primary hyperparathyroidism, thyrotoxicosis, malabsorption, etc.)

Sponsors & Collaborators

• Gaziler Physical Medicine and Rehabilitation Education and Research Hospital: lead

Study Sites (1)

Sbü Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştirma Hastanesi

Ankara, 06800, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Stroke; Osteoporosis

Interventions

Bone Density

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Engin Koyuncu, Prof.

  SBÜ ANKARA GAZİLER FİZİK TEDAVİ VE REHABİLİTASYON EĞİTİM VE ARAŞTIRMA HASTANESİ

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof

Study Record Dates

• First Submitted: July 1, 2025
• First Posted: July 10, 2025
• Study Start: July 11, 2025
• Primary Completion: March 25, 2026
• Study Completion: March 25, 2026
• Last Updated: March 30, 2026

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)