Effectiveness of Isokinetic Exercises in Proprioception for Post-stroke Patients

NCT07106619 | Recruiting

• 1 other identifier: AEŞH-EK-2025-012
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. In addition, recent studies have emphasised that sensory information obtained by target-oriented exercises plays an important role in neuroplasticity and proprioception is an important element. The aim of this study was to evaluate the effect of knee isokinetic muscle strengthening exercises on proprioception and balance in stroke patients.

Conditions

Stroke

Keywords

stroke rehabilitation; proprioception; isokinetic exercise

Outcome Measures

Primary Outcomes (1)

• Proprioception assessment with isokinetic test device

  before treatment and at the 3rd week of treatment

Secondary Outcomes (2)

• Berg scale

  Before treatment and at 3rd week of treatment

• Time up and Go Test

  Before treatment and at the 3rd week of treatment

Study Arms (2)

Conventional Rehabilitation

ACTIVE COMPARATOR

Patients will receive 15 sessions of conventional rehabilitation

Other: Conventional rehabilitation program

isokinetic Exercise

EXPERIMENTAL

Patients will receive 15 sessions of conventional rehabilitation and 10 sessions of knee isokinetic strengthening exercise therapy for the paretic lower extremity for 3 weeks. Isokinetic strengthening exercises will be performed using Cybex 770, Humac Norm dynamometer (CSMI, Stoughton, MA, USA).

Device: Isokinetic Exercises; Other: Conventional rehabilitation program

Interventions

Conventional rehabilitation program OTHER

Ambulation and balance exercises

Conventional Rehabilitation; isokinetic Exercise

Isokinetic Exercises DEVICE

Exercises will be performed at three different angular speeds (90 ̊/sec, 5 repetitions, 5 sets; 120 ̊/sec, 8 repetitions, 5 sets; 150 ̊/sec, 10 repetitions, 5 sets).

isokinetic Exercise

Eligibility Criteria

• Age: 35 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 3 months and no more than 1 year must have passed since the date of the incident
• Be between 35 and 75 years of age
• Manual muscle testing of the affected lower extremity shows at least 3 in ankle dorsiflexion and knee extension
• No limitation in passive joint range of motion in the lower extremity
• Mini mental test score \> 23

You may not qualify if:

• Presence of spasticity according to the modified Ashworth scale \> 1+
• Presence of neurological disease other than stroke
• Presence of other medical conditions that may cause sensorimotor dysfunction in the lower extremities (e.g., diabetic polyneuropathy)
• Presence of orthopaedic problems affecting lower extremity function
• Previous history of stroke or ischaemic attack
• Poor general health status (e.g. severe heart failure, COPD)

Sponsors & Collaborators

• Ankara Etlik City Hospital: lead

Study Sites (1)

Ankara Etlik City Hospital

Ankara, Yenimahalle, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Ayşe Naz Kalem Özgen, specialist

CONTACT

+90 0312 797 00 00; kalemnaz@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist

Study Record Dates

• First Submitted: July 23, 2025
• First Posted: August 6, 2025
• Study Start: August 1, 2025
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: February 24, 2026

Record last verified: 2025-07

Locations

TU (1)