Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites

NCT07057557 | Recruiting

• 1 other identifier: 396/RC/KEMU
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if Aloe Vera gel dressing helps reduce pain better than traditional paraffin-based tulle dressing at the donor site of split-thickness skin grafts in adult patients aged 18 to 60. The main questions it aims to answer are: Does Aloe Vera gel dressing reduce postoperative pain more effectively than paraffin-based tulle dressing on the 7th day after surgery? Is there a difference in the need for additional pain medication between the two groups? Researchers will compare Aloe Vera gel dressing to paraffin-based tulle dressing to see if Aloe Vera leads to better pain control. Participants will: Undergo split-thickness skin graft surgery Receive either Aloe Vera gel dressing or paraffin-based tulle dressing at the donor site Have pain measured using a visual analogue scale (VAS) on the 7th day after surgery Be given pain medication if their pain score is 4 or higher, and the amount used will be recorded

Conditions

Skin Graft Wounds; Donor Site Complication; Pain, Postoperative; Skin Transplantation

Outcome Measures

Primary Outcomes (1)

• Pain Score at Donor Site on Postoperative Day 7

  Postoperative pain will be measured using the Visual Analogue Scale (VAS), which ranges from 0 (no pain) to 10 (worst possible pain).

  7 days after surgery

Study Arms (2)

Aloe Vera Gel Dressing

EXPERIMENTAL

Participants in this group will receive Aloe Vera gel applied directly to the split-thickness skin graft donor site

Other: Aloe Vera Gel Dressing

Paraffin-Based Tulle Dressing (Conventional Dressing)

ACTIVE COMPARATOR

Participants in this group will receive standard paraffin-based tulle dressing with chlorhexidine on the donor site.

Other: Paraffin-Based Tulle Dressing

Interventions

Aloe Vera Gel Dressing OTHER

Participants in this arm will receive Aloe Vera gel applied directly to the split-thickness skin graft (STSG) donor site immediately after graft harvesting. The Aloe Vera gel will be applied in a sterile manner, followed by secondary dressing with dry gauze and crepe bandage. Pain will be assessed on postoperative day 7 using the Visual Analogue Scale (VAS).

Aloe Vera Gel Dressing

Paraffin-Based Tulle Dressing OTHER

Participants in this arm will receive a conventional paraffin-based tulle dressing impregnated with chlorhexidine applied to the STSG donor site. The dressing will be followed by secondary coverage with dry gauze and crepe bandage. Pain will be assessed on postoperative day 7 using the Visual Analogue Scale (VAS).

Paraffin-Based Tulle Dressing (Conventional Dressing)

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18-60 years of age of either gender needing Split thickness skin graft

You may not qualify if:

• Patients known to have exaggerated/diminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.)
• Patients allergic to either dressings

Sponsors & Collaborators

• King Edward Medical University: lead

Study Sites (1)

Mayo Hospital Lahore

Lahore, Punjab Province, Pakistan

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Interventions

aloe vera gel extract hydrogel dressing

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2025
• First Posted: July 10, 2025
• Study Start: August 5, 2025
• Primary Completion: February 5, 2026
• Study Completion: April 14, 2026
• Last Updated: September 25, 2025

Record last verified: 2025-09

Locations

PA (1)