Effect Of Nigella Sativa Oil for the Treatment of Hypertension
1 other identifier
interventional
60
1 country
1
Brief Summary
My research explores the antihypertensive effects of Nigella sativa (black seed) oil in managing high blood pressure. Hypertension is a growing global health concern, often insufficiently controlled by standard medications. Nigella sativa, known for its bioactive compound thymoquinone, possesses antioxidant, anti-inflammatory, and vasodilatory properties, making it a potential natural remedy for blood pressure regulation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable hypertension
Started Mar 2022
Longer than P75 for not_applicable hypertension
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 17, 2022
CompletedFirst Submitted
Initial submission to the registry
June 28, 2025
CompletedFirst Posted
Study publicly available on registry
July 9, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2026
CompletedJuly 9, 2025
June 1, 2025
3.5 years
June 28, 2025
July 8, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Structured Patient History Questionnaire
A pre-designed, structured questionnaire will be used at baseline to collect demographic information, medical history, medication use, dietary habits, and lifestyle factors. This is a qualitative tool without a scoring system but is essential for eligibility confirmation and contextual analysis
12 Months
Study Arms (2)
Nigella sativa Oil Supplementation
EXPERIMENTALNo Intervention (Control Group)
NO INTERVENTIONInterventions
Participants in Group 1 (intervention group) will receive Nigella sativa (black seed) oil at a dosage of 0.5 ml, administered orally twice daily-once before breakfast and once before bedtime-for a duration of 12 weeks. The oil, sourced from a standardized local supplier, is rich in thymoquinone, known for its antioxidant and vasodilatory properties. Blood pressure will be measured at baseline and biweekly intervals using a calibrated digital sphygmomanometer to monitor changes in systolic and diastolic values. Participants will also be monitored regularly for any adverse effects.
Eligibility Criteria
You may qualify if:
- Adults aged 30 to 70 years
- Diagnosed with mild to moderate hypertension (BP ≥140/90 mmHg)
- Willing to participate and provide written informed consent
- Not currently on any herbal or nutritional supplements
You may not qualify if:
- History of smoking or alcohol consumption
- Pregnant, postmenopausal, or breastfeeding women
- Use of dietary supplements or medications containing antioxidants, caffeine, estrogen, or steroids
- Individuals engaging in regular vigorous physical exercise
- Those adding extra salt to their meals
- Known allergy to Nigella sativa or black seed oil
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Bahria Town
Lahore, Punjab Province, Pakistan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
June 28, 2025
First Posted
July 9, 2025
Study Start
March 17, 2022
Primary Completion
September 1, 2025
Study Completion
February 28, 2026
Last Updated
July 9, 2025
Record last verified: 2025-06
Data Sharing
- IPD Sharing
- Will not share