The Effect of Aerobic Exercise on Selective Biomarkers of Patients With Cancer

NCT07048847 | Completed

• 1 other identifier: BakircayU-579/559
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a single-blinded, prospective, controlled trial aiming to evaluate the effect of supervised aerobic exercise on adipokine and myokine biomarkers in patients with breast or colon cancer during their systemic chemotherapy.

Conditions

Breast Cancer; Colon Cancer; Chemotherapy Effect

Keywords

Adiponectin; Cancer; Exercise; Irisin; IL-6; Leptin

Outcome Measures

Primary Outcomes (8)

• Irisin

  Measuring Serum levels of Irisin via ELISA

  Baseline

• Irisin

  Measuring Serum levels of Irisin via ELISA

  From completion of systemic chemotherapy up to one week

• Leptin

  Measuring Serum levels of Leptin via ELISA

  Baseline

• Leptin

  Measuring Serum levels of Leptin via ELISA

  From completion of systemic chemotherapy up to one week

• Adiponectin

  Measuring Serum levels of Adiponectin via ELISA

  Baseline

• Adiponectin

  Measuring Serum levels of Adiponectin via ELISA

  From completion of systemic chemotherapy up to one week

• Interleukin-6 (IL-6)

  Measuring Serum levels of IL-6 via ELISA

  Baseline

• Interleukin-6 (IL-6)

  Measuring Serum levels of IL-6 via ELISA

  From completion of systemic chemotherapy up to one week

Study Arms (2)

Exercise Group

Patients who will be willing to participate in supervised exercise will be grouped in Exercise Group (EG).

Other: Exercise

Control Group

Patients who are not willing to participate in exercise due to various reasons (time restrictions, other obligations, transport, etc.) will be grouped in the Control Group (CG).

Interventions

Exercise OTHER

The exercise program will be started with 25 Watt (W) for 5 minutes of warm-up. Then it is steadily increased automatically by 5W in 5 minutes apart for 25 minutes for the loading period. The last 5 minutes which will be started by lowering the load to 25 W for cooling will be implemented for cooling down. To prevent acommodation, the warm-up period will be modified by increasing nearly 10% of its previous rate three weeks apart.A submaximal exercise prescription will be followed according to the American College of Sports Medicine guideline by taking into attention 50-70% of Heart Rate Reserve.A submaximal exercise prescription will be followed according to the American College of Sports Medicine guideline by taking into attention 50-70% of Heart Rate Reserve.

Also known as: Control

Exercise Group

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Having been diagnosed with solid type of cancer (specifically breast or colon) and being candidate for undergoing systemic chemotherapy.

You may qualify if:

• Having been diagnosed with solid type of cancer
• Being candidate for systemic chemotherapy
• Being volunteer to participate in an exercise program
• Aged between 18-70 years old

You may not qualify if:

• Having 2 or above grades according to the Eastern Cooperative Oncology Group (ECOG) performance status
• Having mental and/or cognitive deficits
• Ongoing medical and/or surgical (if any) complications
• Having neurological/orthopedical and/or severe respiratory dysfunctions
• Having any condition which corresponds to the contraindication of exercise (i.e. advanced stages, distant metastasis, infection)
• Having unstable vital parameters or having regularly used pharmacological interventions

Sponsors & Collaborators

• Izmir Bakircay University: lead

Study Sites (1)

Bakircay University Çiğli State and Training Hospital, Department of Medical Oncology

Izmir, Çiğli, 35620, Turkey (Türkiye)

Location

Related Publications (7)

• Brownson-Smith R, Orange ST, Cresti N, Hunt K, Saxton J, Temesi J. Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis. J Cancer Surviv. 2025 Feb;19(1):78-96. doi: 10.1007/s11764-023-01450-w. Epub 2023 Aug 24.

  PMID: 37615928 BACKGROUND

• Kim JS, Galvao DA, Newton RU, Gray E, Taaffe DR. Exercise-induced myokines and their effect on prostate cancer. Nat Rev Urol. 2021 Sep;18(9):519-542. doi: 10.1038/s41585-021-00476-y. Epub 2021 Jun 22.

  PMID: 34158658 BACKGROUND

• Tsiani E, Tsakiridis N, Kouvelioti R, Jaglanian A, Klentrou P. Current Evidence of the Role of the Myokine Irisin in Cancer. Cancers (Basel). 2021 May 27;13(11):2628. doi: 10.3390/cancers13112628.

  PMID: 34071869 BACKGROUND

• Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, Spicer DV, Tripathy D, Bernstein L, Mortimer JE. Effects of Aerobic and Resistance Exercise on Metabolic Syndrome, Sarcopenic Obesity, and Circulating Biomarkers in Overweight or Obese Survivors of Breast Cancer: A Randomized Controlled Trial. J Clin Oncol. 2018 Mar 20;36(9):875-883. doi: 10.1200/JCO.2017.75.7526. Epub 2018 Jan 22.

  PMID: 29356607 BACKGROUND

• Meneses-Echavez JF, Correa-Bautista JE, Gonzalez-Jimenez E, Schmidt Rio-Valle J, Elkins MR, Lobelo F, Ramirez-Velez R. The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis. Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1009-17. doi: 10.1158/1055-9965.EPI-15-1061. Epub 2016 Apr 12.

  PMID: 27197276 BACKGROUND

• Tjoe JA, Piacentine LB, Papanek PE, Raff H, Richards J, Harkins AL, Yin J, Ng AV. Team triathlon effects on physiological, psychological, and immunological measures in women breast cancer survivors. Support Care Cancer. 2020 Dec;28(12):6095-6104. doi: 10.1007/s00520-020-05457-2. Epub 2020 Apr 20.

  PMID: 32314053 BACKGROUND

• Tugral A, Aribas Z, Kaya Ucar G, Arslan FD, Bakar Y, Karakoyun I, Akyol M. The effect of supervised aerobic exercise on adipokine and myokine biomarkers in patients with cancer during systemic chemotherapy: a single-blinded prospective controlled trial. Support Care Cancer. 2025 Aug 2;33(8):741. doi: 10.1007/s00520-025-09788-w.

  PMID: 40751845 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

For both EG and CG, two blood samplings were performed for each patient. 5 cc venous blood was collected from all the participants and centrifuged at 1500 g for 10 minutes. Separated serum was stored at -20 °C until analysis. Serum leptin, IL-6, irisin, and adiponectin concentrations were measured by using enzyme-linked immunosorbent assay (ELISA) method.

MeSH Terms

Conditions

Breast Neoplasms; Colonic Neoplasms; Neoplasms; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Neoplasms by Site; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Alper Tuğral, PhD

  Izmir Bakircay University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Project Coordinator

Study Record Dates

• First Submitted: June 10, 2025
• First Posted: July 3, 2025
• Study Start: September 15, 2022
• Primary Completion: August 15, 2023
• Study Completion: December 1, 2023
• Last Updated: July 3, 2025

Record last verified: 2025-06

Locations

TU (1)