Uric Acid and Menopausal Age in Acute Kidney Injury

NCT07044934 | Completed

• 1 other identifier: AMC [2024-1090]
• Study Type: observational
• Target: 127,052
• Locations: 1 country
• Sites: 1

Brief Summary

Preoperative serum uric acid significantly impacted acute kidney injury in female patients undergoing non-cardiac surgery, with differential effects observed before and after menopause.

Conditions

Uric Acid

Keywords

uric acid; female; non cardiac; acute kindeny injury; menopause

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative Acute Kidney Injury

  7 days post-surgery

Study Arms (2)

Premenopausal Women

Other: No Intervention: Observational Cohort

Postmenopausal Women

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).

Postmenopausal Women; Premenopausal Women

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included female patients aged 18 years or older who underwent elective non-cardiac surgery at a tertiary medical center. For patients who underwent multiple surgeries during the study period, only the first procedure following hospital admission was analyzed. The exclusion criteria were as follows: patients with a history of gout; those who had undergone nephrectomy or kidney transplantation (either as donors or recipients); patients diagnosed with chronic kidney disease or those who had received kidney replacement therapy; patients with an estimated glomerular filtration rate of less than 30 mL/min/1.73 m²; and those with incomplete clinical data or missing laboratory values.

You may qualify if:

• Female patients aged 18 years and older who underwent elective non-cardiac surgery

You may not qualify if:

• Patients with gout
• Patients who underwent nephrectomy or kidney transplantation (either as recipients or donors)
• Patients diagnosed with chronic kidney disease or who had already undergone kidney replacement therapy
• Patients with estimated glomerular filtration rate \< 30 mL/min/1.73m²; and patients with incomplete data or missing laboratory values

Sponsors & Collaborators

• Asan Medical Center: lead

Study Sites (1)

Asan Medical Center

Seoul, Songpa, 05505, South Korea

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 21, 2025
• First Posted: July 1, 2025
• Study Start: July 30, 2024
• Primary Completion: December 20, 2024
• Study Completion: February 20, 2025
• Last Updated: July 2, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)