Effect of Modified Poco-Poco Exercise to Aging Biomarkers in Elderly

NCT07042464 | Completed

• 1 other identifier: IKFR.11_2.06.25
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Subject with sarcopenia get modified poco-poco exercise program for 12 weeks

Conditions

Geriatrics Rehabilitation

Outcome Measures

Primary Outcomes (5)

• Sarcopenia Staging (Skeletal Muscle Index)

  Skeletal muscle index

  12 weeks

• Sarcopenia Staging (Muscle Strength)

  Hand Grip Strength, score in kilograms

  12 weeks

• Sarcopenia Staging (Physical Performance)

  Short Physical Performance Battery, score in numerical 0-12

  12 weeks

• Levels of Global DNA Methylation

  Global DNA methylation levels were analyzed using the ELISA-based kit

  12 weeks

• Levels of Growth Differentiation Factor 15

  Growth Differentiation Factor 15 were analyzed the Quantikine ELISA Human GDF-15 Immunoassay

  12 weeks

Study Arms (1)

Modified poco-poco exercises

EXPERIMENTAL

Participants performed modified poco-poco exercises three times weekly for 12 weeks and were assessed, including sarcopenia staging (determined by assessing skeletal muscle index, muscle strength, physical performance) and levels of global DNA methylation and GDF-15

Procedure: Modified poco-poco exercises

Interventions

Modified poco-poco exercises PROCEDURE

Participants performed modified poco-poco exercises three times weekly for 12 weeks

Modified poco-poco exercises

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age above 60 years old
• Have sarcopenia (based on AWGSOP 2019 criteria)

You may not qualify if:

• Hearing impairment/loss hindering participants to receive verbal instructions
• Vision impairment/loss hindering participants to receive instructions
• Musculoskeletal impairment or severe joint diseases (i.e. deformity in Osteoarthritis or Rheumatoid Arthritis)
• Participants have been involved in other exercise program
• Severe cardiovascular disease diagnosed by Cardiologist.
• Participants will be excluded from the research if they skip 3 sessions of the program consecutively or skip 5 sessions cumulatively

Sponsors & Collaborators

• Universitas Padjadjaran: lead

Study Sites (1)

Hasan Sadikin General Hospital

Bandung, Indonesia

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: All research subjects received modified poco-poco exercise program for 12 weeks

Study Record Dates

• First Submitted: June 11, 2025
• First Posted: June 29, 2025
• Study Start: June 20, 2025
• Primary Completion: September 20, 2025
• Study Completion: September 20, 2025
• Last Updated: May 6, 2026

Record last verified: 2026-04

Locations

ID (1)