NCT07038317

Brief Summary

The goal of this study is to examine if e-cigarette education messages delivered using a source and presentation tailored to one's vaping status influences young adults' vaping behaviors. The main questions it aims to answer are:

  1. 1.Does receiving e-cigarette education messages presented using a source (expert or peer) and sidedness (one or two-sided) optimized for the current vaper group influence vaping cessation among young adults who vape daily?
  2. 2.Does receiving e-cigarette education messages presented using a source (expert or peer) and sidedness (one or two-sided) optimized for the non-vaper group influence vaping initiation among young adults who are susceptible to vaping? Participants will be randomly assigned to either the treatment (receiving messages tailored to one's vaping status) or the control (receiving non-tobacco messages) condition and receive SMS three times per week over the course of 6 months. They will complete self-report assessment and show salivary cotinine results for nicotine testing at 4 timepoints.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
20mo left

Started Jan 2026

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress16%
Jan 2026Dec 2027

First Submitted

Initial submission to the registry

June 10, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

June 26, 2025

Completed
7 months until next milestone

Study Start

First participant enrolled

January 15, 2026

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2027

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

November 21, 2025

Status Verified

November 1, 2025

Enrollment Period

1.5 years

First QC Date

June 10, 2025

Last Update Submit

November 19, 2025

Conditions

Vaping BehaviorsMessage ExposureYoung Adults

Outcome Measures

Primary Outcomes (2)

  • Self-reported vaping

    Past-30-day vaping (yes/no) will be assessed

    Baseline, six-month

  • Biochemical confirmation of vaping

    Salivary cotinine for nicotine testing

    Baseline, one-month, three-month, six-month

Secondary Outcomes (5)

  • Harm perceptions

    Baseline, one-month, three-month, six-month

  • Message perceptions

    One-month, three-month, six-month

  • Message liking

    One-month, three-month, six-month

  • Number of days of past-30-day e-cigarette use

    From enrollment to the end of study at 24 weeks.

  • E-cigarette accessibility

    Baseline, one-month, three-month, six-month

Study Arms (2)

Treatment

EXPERIMENTAL

Participants in the treatment arm will receive e-cigarette education messages with source and sidedness optimized to one's vaping status.

Other: Intervention

Control

PLACEBO COMPARATOR

Participants in the control arm will receive messages about sun safety.

Other: Control

Interventions

InterventionOTHER

Intervention involves e-cigarette education messages tailored to participants' vaping status that will be sent out in SMS via text messaging three times per week over the course of 6 months.

Treatment
ControlOTHER

Participants will receive non-tobacco messages (messages about sun safety) three times per week over the course of 6 months.

Control

Eligibility Criteria

Age18 Years - 24 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • years old
  • Fluent in English
  • Not currently using tobacco products other than e-cigarettes at the time of enrollment
  • Have a mobile phone to send and receive text messages

You may not qualify if:

  • Age below 18 or above 24
  • Not being fluent in English
  • Currently using tobacco products other than e-cigarettes
  • Not having a mobile phone

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Hawaii Cancer Center

Honolulu, Hawaii, 96822, United States

Location

MeSH Terms

Interventions

Methods

Intervention Hierarchy (Ancestors)

Investigative Techniques

Central Study Contacts

Donghee N Lee, PhD

CONTACT

808-441-8184nlee@cc.hawaii.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

June 10, 2025

First Posted

June 26, 2025

Study Start

January 15, 2026

Primary Completion (Estimated)

June 30, 2027

Study Completion (Estimated)

December 31, 2027

Last Updated

November 21, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will share

De-identified participants dataset will be shared.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
One year after the completion of study

Locations

US(1)