Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?

NCT07472244 | Recruiting

• 1 other identifier: 11104-14846
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise . However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects

Conditions

Exercise Recovery

Outcome Measures

Primary Outcomes (1)

• Muscle Function

  Jump height calculated through flight time

  Baseline and post exercise (2 hours, 1 day, 7 day)

Secondary Outcomes (4)

• Muscle Function

  Baseline and post exercise (2 hours, 1 day, 7 day)

• Muscle Function

  Baseline and post exercise (2 hours, 1 day, 7 day)

• Muscle Function

  Baseline and post exercise (2 hours, 1 day, 7 day)

• Creatine Kinase

  Baseline and immediately, 1-h (hour)-, 2-h-, 24-h-,and 48-hours-post-exercise

Study Arms (2)

Intervention

EXPERIMENTAL

Vitamin C and Non-steroidal anti-inflammatory drug

Dietary Supplement: Intervention

Control

PLACEBO COMPARATOR

Identical Placebo

Dietary Supplement: Control

Interventions

Control DIETARY_SUPPLEMENT

Identical maltodextrin tablet. Appearance and weight matched

Control

Intervention DIETARY_SUPPLEMENT

1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h

Intervention

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years of age
• BMI 18.5 - 29.9 kg/m2
• Able to perform 20-minutes of bench stepping exercise
• Capable and willing to provide consent (oral and written)

You may not qualify if:

• Familiarised with bench stepping exercise procedures
• Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
• Participants exhibiting any alteration in clinical inflammation parameters due to other cause
• Participants currently being prescribed any anti-inflammatory medications

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

University of Bath

Bath, United Kingdom

RECRUITING

MeSH Terms

Interventions

Methods

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Investigator

Model Details: The proposed study is a randomised, double blind, placebo controlled, parallel-group study

Study Record Dates

• First Submitted: March 4, 2026
• First Posted: March 16, 2026
• Study Start: September 1, 2025
• Primary Completion (Estimated): February 28, 2027
• Study Completion (Estimated): February 28, 2027
• Last Updated: March 16, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share

Locations

GB (1)