Metabotyping of Broccoli Microgreen in Obese Breast Cancer Survivors

NCT07032545 | Recruiting DMC

• 1 other identifier: HP-00113949
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity can pose significant challenges to maintaining long-term health in cancer survivors by increasing their risk of cancer coming back. Eating a healthy diet is an important way to help manage weight and improve overall health. Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer. Previous studies in mice showed that BMG can improve gut health and metabolism, leading to better health outcomes in obese animals. This study will test whether BMG can be a useful addition to the diet of obese breast cancer (BC) survivors who have a higher risk of their cancer returning. 24 obese BC survivors will be invited to eat one serving (one cup, \~57 gram) of fresh BMG every day for two weeks. This will help understand if people can stick to this diet, how their bodies respond, and whether it affects metabolism and inflammation-two key factors linked to cancer risk. Biological markers such as body fat, glucose and lipids as well as gut bacterial changes will be analyzed to see how BMG affects individual health. This study may help create new diet strategies to improve health, reduce cancer risk, and support long-term recovery in cancer patients who are overweight or obese. In the future, this research could help doctors personalize nutrition plans to better support cancer survivors.

Conditions

Obesity and Overweight; Breast Cancer Survivorship

Keywords

breast cancer; broccoli microgreen; obesity; survivorship; gut microbiome; metabolomics; metabotyping

Outcome Measures

Primary Outcomes (2)

• Feasibility, as Assessed by the Percentage of Participants Who Enrolled and Completed the Study

  Feasibility will be assessed by calculating the percentage of participants who enrolled and completed the study by providing evaluable data at baseline, during the BMG intervention and after 2-weeks treatment.

  14 days

• Compliance, as Assessed by the Percentage of the Participants Who Adhere to the Assigned BMG Intervention

  Compliance will be assessed by measuring the percent of the participants who consume the assigned BMG through the recommended cooking method during the 2-weeks of intervention period.

  14 days

Secondary Outcomes (4)

• Body Composition, as Assessed by the Percentage of the Body Fat

  14 days

• Blood Glucose, as Assessed by Fasting Blood Glucose Level

  14 days

• Blood Lipids, as Assessed by Blood Lipid Concentrations

  14 days

• The Gut microbiome, as Assessed by the Bacterial Composition Changes

  14 days

Study Arms (1)

BMG

EXPERIMENTAL

All participants are in BMG group and will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.

Other: Broccoli microgreen (BMG)

Interventions

Broccoli microgreen (BMG) OTHER

All participants will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.

BMG

Eligibility Criteria

• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Female
• Had a diagnosis of breast cancer (Stage I-III)
• to 60 months post-curative treatment (surgery, chemotherapy, and/or radiation)
• BMI \> 30 kg/m² (obese classification)
• Willing to avoid cruciferous vegetables during the study
• Able to sign an IRB-approved consent form

You may not qualify if:

• Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., GI conditions, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder).
• Allergy or intolerance to cruciferous vegetables
• Currently taking broccoli extract supplements

Sponsors & Collaborators

• University of Maryland, Baltimore: lead
• University of Maryland, College Park: collaborator

Study Sites (1)

Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States

RECRUITING

Related Publications (3)

• Bankole T, Ma T, Arora I, Lei Z, Raju M, Li Z, Li Y. The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High-Fat-Diet-Induced Obesity through the Gut Microbiome and Metabolome Interface. Mol Nutr Food Res. 2024 May;68(9):e2300856. doi: 10.1002/mnfr.202300856. Epub 2024 Apr 27.

  PMID: 38676466 BACKGROUND

• Turner ER, Luo Y, Buchanan RL. Microgreen nutrition, food safety, and shelf life: A review. J Food Sci. 2020 Apr;85(4):870-882. doi: 10.1111/1750-3841.15049. Epub 2020 Mar 6.

  PMID: 32144769 BACKGROUND

• Wojdylo A, Nowicka P, Tkacz K, Turkiewicz IP. Sprouts vs. Microgreens as Novel Functional Foods: Variation of Nutritional and Phytochemical Profiles and Their In Vitro Bioactive Properties. Molecules. 2020 Oct 12;25(20):4648. doi: 10.3390/molecules25204648.

  PMID: 33053861 BACKGROUND

MeSH Terms

Conditions

Obesity; Overweight; Breast Neoplasms

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Yuanyuan (Rose) Li, M.D., Ph.D.

  University of Maryland

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuanyuan (Rose) Li, M.D., Ph.D.

CONTACT

13014050776; roseli15@umd.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: This is a single arm pilot intervention trial and all participants will be asked to consume allocated broccoli microgreen for 2 weeks.

Study Record Dates

• First Submitted: June 10, 2025
• First Posted: June 24, 2025
• Study Start: December 3, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2028
• Last Updated: December 23, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)