A Randomized Controlled Trial Comparing the Efficacy of Commercial Weight Management Programs

NCT06972277 | Completed

• 1 other identifier: The ACE Study
• Study Type: interventional
• Target: 459
• Locations: 1 country
• Sites: 1

Brief Summary

The study compares the effectiveness of three commercial weight management programs. The primary outcome is absolute and percentage weight change at 12-weeks.

Conditions

Obesity and Overweight

Outcome Measures

Primary Outcomes (2)

• Percent body weight lost at 12 weeks

  Measurement of weight using a body weight scale

  Baseline, 4 weeks, 8 weeks, 12 weeks

• Change in body weight (in kg or pounds) at 12 weeks

  Measurement of weight using a body weight scale

  Baseline, 4 weeks, 8 weeks, 12 weeks

Secondary Outcomes (9)

• Physical Activity and Sedentary Behavior

  Baseline, 12 weeks

• Dietary intake

  Baseline, 12 weeks

• Hunger

  Baseline, 12 weeks

• Impact of Weight on Quality

  Baseline, 12 weeks

• Wellbeing

  Baseline, 12 weeks

Study Arms (3)

Commercial weight management program 1

EXPERIMENTAL

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Behavioral: Commercial weight management program

Commercial weight management program 2

EXPERIMENTAL

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Behavioral: Commercial weight management program

Commercial weight management program 3

EXPERIMENTAL

Participants in this group receive behavioral / lifestyle support from an evidence-based commercial weight management program.

Behavioral: Commercial weight management program

Interventions

Commercial weight management program BEHAVIORAL

Participants will receive evidence-based behavioral / lifestyle support from a commercial weight management program.

Commercial weight management program 1; Commercial weight management program 2; Commercial weight management program 3

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years or older
• BMI ≥27 kg/m²
• Own a bodyweight scale that they can weigh themselves with during the study
• Willing and able to comply with study protocol
• Capable of providing informed consent
• Able to read and write in English
• Willing to be randomized
• Willing to sign a Non Disclosure Agreement

You may not qualify if:

• Pregnant, lactating, or plans to become pregnant in the next 6 months
• Previous bariatric surgery or planned bariatric surgery during the study period
• Major surgery within the past 6 months or plans to have surgery during the study period
• Participation in the previous 3 months or current participation in a structured behavioral weight loss program
• Participation in another structured weight loss program during the study period (i.e., the next 3 months)
• Communication needs that would render them unable to understand the study and/or intervention materials
• Current or previous history of anorexia or bulimia nervosa
• Engagement with vomiting or laxative use within the last 28 days with the aim of controlling their shape or weight
• Currently taking anti-obesity medications, planning to take anti-obesity medications in the next 6 months, or previously taken anti-obesity medications in the previous 3 months
• Weight loss of ≥ 5 kg (11 lb) in the previous 6 months
• Self-reported diagnosis of severe depression, bipolar disorder, substance abuse, or psychosis
• Participants who are involved in any other research studies at this time
• Untreated thyroid disease or any changes (type or dose) in thyroid medication in last 6 months
• Chronic/inflammatory gastrointestinal disorders (irritable bowel syndrome is acceptable)
• History of heart problems (e.g., angina, bypass surgery, myocardial infarction, etc.) within previous 6 months

Sponsors & Collaborators

• WW International Inc: lead

Study Sites (1)

WW International, Inc

New York, New York, 10010, United States

Location

MeSH Terms

Conditions

Obesity; Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Kara Marlatt, PhD, MPH

  WW International Inc

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Director, Scientific Research

Study Record Dates

• First Submitted: May 6, 2025
• First Posted: May 14, 2025
• Study Start: May 14, 2025
• Primary Completion: January 9, 2026
• Study Completion: January 9, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-01

Locations

US (1)