Predicting and Monitoring Spontaneous Bacterial Peritonitis in Cirrhotic Patients Using the Mansoura Scoring System

NCT07024355 | Not Yet Recruiting

• 1 other identifier: 04-2025-300593
• Study Type: observational
• Target: 250
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this prospective study was to examine predictors of SBP in order to develop a noninvasive method to identify or exclude an episode of SBP, for starting early treatment with antibiotics, so decrease morbidity and mortality in these patients.

Conditions

Spontaneous Bacterial Peritonitis

Outcome Measures

Primary Outcomes (1)

• Diagnostic Accuracy of the Mansoura Scoring System for Predicting Spontaneous Bacterial Peritonitis (SBP)

  Primary Outcome Measure Title:Diagnostic Accuracy of the Mansoura Scoring System for Predicting Spontaneous Bacterial Peritonitis (SBP) Description: Evaluation of the diagnostic performance of the Mansoura scoring system in predicting spontaneous bacterial peritonitis (SBP), using ascitic fluid neutrophil count \>250 cells/mm³ as the reference standard. Diagnostic accuracy will be assessed in terms of sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic (ROC) curve. Unit of Measure: Percentage / AUC

  At hospital admission ( within 24 hours of admission)

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This prospective study included all adult patients with cirrhosis and ascites admitted to AL-Rajhy Liver Hospital between April 2025 and April 2027

You may qualify if:

• Adult patients aged \>18 years
• Diagnosed liver cirrhosis
• Presence of ascites
• Provided written informed consent

You may not qualify if:

• Use of antibiotics within the previous two weeks
• Prophylactic treatment for spontaneous bacterial peritonitis (SBP) prior to admission
• Ascites not related to portal hypertension, including:
• Peritoneal tuberculosis
• Peritoneal carcinomatosis
• Congestive heart failure
• Renal disease
• Pancreatitis
• Hemorrhagic ascites
• Secondary peritonitis
• Presence of infections other than SBP, including:
• Pneumonia
• Urinary tract infection
• Skin and soft tissue infection
• Presence of malignancy Hematologic diseases

Sponsors & Collaborators

• Assiut University: lead

Study Officials

• Amira M Abdelmawgod, Lecturer, Trop Med

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amira M Abdelmawgod, Lecturer, Trop Med

CONTACT

01012760437; amiramohmad60@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: April 23, 2025
• First Posted: June 17, 2025
• Study Start: April 1, 2026
• Primary Completion: April 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: January 22, 2026

Record last verified: 2025-06