Measured Versus Estimated Energy Requirement in the ICU Patients

NCT07024264 | Completed

• 1 other identifier: N202409050
• Study Type: observational
• Target: 133
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare energy requirements estimated by predictive equation and indirect calorimetry across different BMI categories, and to examine how these estimates, along with early nutritional strategies and progressive caloric delivery relate to ICU outcomes. The main questions it aims to answer are:

1. 1.To evaluate whether predictive equation and/or indirect calorimetry provides accurate caloric targets in critically ill patients.
2. 2.To identify high-risk malnutrition patients (underweight, normal and overweight, obese) who may benefit most from IC-based measurement.
3. 3.To investigate the impact of caloric strategies and nutritional achievement during the acute phase on the length of ICU stay.

Conditions

Critical Illness; Energy Requirement; Equation; Indirect Calorimetry; Malnutrition

Outcome Measures

Primary Outcomes (1)

• The primary outcome was ICU length of stay.

  This study aimed to compare energy requirements estimated by PE and IC across different BMI categories, and to examine how these estimates, along with early nutritional strategies and progressive caloric delivery relate to the length of ICU stay.

  From admitted to ICU which defined as day 1, until transferred to the general wards or expired, up to 12 weeks.

Interventions

Total energy requirement calculated by predictive equation OTHER

Critically ill patients are highly susceptible to malnutrition, making accurate caloric estimation essential to prevent both underfeeding and overfeeding during the acute phase in the ICU. Although predictive equations (PE) are widely used to estimate energy requirement, indirect calorimetry (IC) remains the gold standard. This study aimed to compare energy requirements estimated by PE and IC across different BMI categories.

Eligibility Criteria

• Age: 20 Years - 105 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to ICU and ventilator dependent in Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare.

You may qualify if:

• Length of ICU stay \> 4 days
• Mechanically ventilated adults (\>20 y/o)
• Tube feeding
• At high risk of malnutrition by Global Leadership Initiative on Malnutrition (GLIM) criteria: underweight and obesity
• Doctor's preference: cachexia, hypermetabolic status, TPN etc.,…

You may not qualify if:

• Length of ICU stay \<4 days
• Mechanically ventilated adults (\<=20 y/o)

Sponsors & Collaborators

• Taipei Medical University Shuang Ho Hospital: lead

Study Sites (1)

Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare

New Taipei City, Taiwan

Location

Related Publications (4)

• McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C; Society of Critical Care Medicine; American Society for Parenteral and Enteral Nutrition. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016 Feb;40(2):159-211. doi: 10.1177/0148607115621863. No abstract available.

  PMID: 26773077 BACKGROUND

• Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, Hiesmayr M, Mayer K, Montejo JC, Pichard C, Preiser JC, van Zanten ARH, Oczkowski S, Szczeklik W, Bischoff SC. ESPEN guideline on clinical nutrition in the intensive care unit. Clin Nutr. 2019 Feb;38(1):48-79. doi: 10.1016/j.clnu.2018.08.037. Epub 2018 Sep 29.

  PMID: 30348463 BACKGROUND

• De Waele E, Jonckheer J, Wischmeyer PE. Indirect calorimetry in critical illness: a new standard of care? Curr Opin Crit Care. 2021 Aug 1;27(4):334-343. doi: 10.1097/MCC.0000000000000844.

  PMID: 33990505 BACKGROUND

• Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016 Nov 10;20(1):367. doi: 10.1186/s13054-016-1538-4.

  PMID: 27832823 BACKGROUND

MeSH Terms

Conditions

Critical Illness; Malnutrition

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 14, 2025
• First Posted: June 17, 2025
• Study Start: October 1, 2022
• Primary Completion: March 31, 2024
• Study Completion: March 31, 2024
• Last Updated: June 17, 2025

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)