Prediction Model of Vitamin D Deficiency

NCT05376774 | Completed

• 1 other identifier: 202203073RIND
• Study Type: observational
• Target: 662
• Locations: 1 country
• Sites: 1

Brief Summary

Many studies have pointed out that patients with vitamin D deficiency have a longer stay in the intensive care unit and a poor prognosis. Previous multi- center prospective observational study in Taiwan reveals that the prevalence of vitamin D deficiency in critically ill patients in northern Taiwan is 59%, and the prevalence of severe vitamin D deficiency is 18%. Several prediction models of vitamin D deficiency had been built for the general population but not patients admitted in intensive care units. This multi-center retrospective study aims to develop and validate a score-based prediction model for severe vitamin D deficiency in critically ill patients. Investigators will review the data of previous multicenter, prospective, observational study. For temporal validation, the data will be divided into a derivation cohort (first 80% of the data set based on chronology) and a validation cohort (the remaining data set). The development and validation of the models will be carried out following the recommendations established in the Transparency Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) initiative.

Conditions

Critical Illness

Keywords

critical care; vitamin D

Outcome Measures

Primary Outcomes (1)

• Performance of the score-based prediction model

  Area under the receiver operating characteristic (AUROC) and area under precision recall curve (AUPRC) of the prediction models for severe vitamin D deficiency

  1 day

Study Arms (1)

Critically ill patients

Patients admitted to intensive care units

Other: Admitted to intensive care units

Interventions

Admitted to intensive care units OTHER

Admitted to intensive care units

Critically ill patients

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critically ill patients

You may qualify if:

• Patients admitted to intensive care units

You may not qualify if:

• aged \< 20 years
• admitted to intensive care unit longer than 28 days
• body max index \< 18 kg/m2
• receive vitamin D supplement \> 3000 IU/day
• previously admitted to intensive care unit within 3 months
• have parathyroid disease, rickets, or severe liver cirrhosis \[Child C\]

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

Department of Anesthesiology, National Taiwan University Hospital

Taipei, 100, Taiwan

Location

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 12, 2022
• First Posted: May 17, 2022
• Study Start: May 1, 2022
• Primary Completion: August 1, 2022
• Study Completion: September 1, 2022
• Last Updated: September 13, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)