A Study on the Effect of Etavopivat on Heart Rhythm in Healthy Participants

NCT07023029 | Completed Phase 1 FDA Drug

• 2 other identifiers: NN7535-7975U1111-1314-5780
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

Novo Nordisk is developing a new study medicine, Etavopivat, to treat individuals with sickle cell disease (SCD). The purpose of the study is to determine the effect of Etavopivat on the electrical activity of the heart in healthy participants. The study comprises two parts: Part A and Part B. Part A investigates the safety of a high dose of Etavopivat. In this phase, participants will receive either a single dose of Etavopivat or a placebo. Which treatment the participant gets is decided by chance. In Part B, participants will get four different treatments on four different occasions: Etavopivat in 2 different doses (the new medicine that cannot be prescribed), a dummy medicine (placebo), and an already approved medicine (moxifloxacin). The order of the 4 study medicines is decided by chance. There will be a break of 7 days between each treatment. For Part A, the study duration will be from 10 to 36 days, and for Part B, the study duration will be from 27 to 53 days.

Conditions

Healthy Volunteers; Sickle Cell Disease; Thalassemia

Outcome Measures

Primary Outcomes (2)

• Part A: Number of treatment-emergent adverse events (AEs)

  Measured as count of events.

  From dosing (Day 1) until end of study (Day 8)

• Part B: Change from baseline in Fridericia heart rate corrected QT interval (ΔQTcF) for etavopivat

  Measured as milliseconds.

  From pre-dose to post etavopivat/ etavopivat placebo dose on day 1 to day 23

Secondary Outcomes (18)

• Part A: Number of treatment-emergent clinically significant abnormal findings in electrocardiogram (ECGs)

  From dosing (Day 1) until end of study (Day 8)

• Parts A and B: Cmax,etavopivat- Maximum observed etavopivat plasma concentration after a single dose

  Day 1 (Part B)/ From day 1 to day 5 (Part A) after investigational medicinal product (IMP) administration

• Parts A and B: AUC0-last,etavopivat- Area under the etavopivat plasma concentration-time curve from 0 hours to the time of last quantifiable concentration

  Day 1 (Part B)/ From day 1 to day 5 (Part A) after IMP administration

• Parts A and B: AUC0-inf,etavopivat- Area under the etavopivat plasma concentration-time curve from 0 hours and extrapolated to infinity after a single dose

  Day 1 (Part B)/ From day 1 to day 5 (Part A) after IMP administration

• Parts A and B: tmax,etavopivat- Time to maximum observed etavopivat plasma concentration after a single dose

  Day 1 (Part B)/ From day 1 to day 5 (Part A) after IMP administration

Study Arms (5)

Part A- Etavopivat

EXPERIMENTAL

Participants will receive a single dose of etavopivat.

Drug: Etavopivat

Part A- Placebo

PLACEBO COMPARATOR

Participants will receive a single dose of placebo.

Drug: Placebo

Part B- Etavopivat

EXPERIMENTAL

Participants will receive a single dose of etavopivat.

Drug: Etavopivat

Part B- Moxifloxacin

OTHER

Participants will receive a single dose of moxifloxacin.

Drug: Moxifloxacin

Part B- Placebo

PLACEBO COMPARATOR

Participants will receive a single dose of placebo.

Drug: Placebo

Interventions

Etavopivat DRUG

Etavopivat will be administered orally.

Part A- Etavopivat; Part B- Etavopivat

Moxifloxacin DRUG

Moxifloxacin will be administered orally.

Part B- Moxifloxacin

Placebo DRUG

Placebo matching Etavopivat will be administered orally.

Part A- Placebo; Part B- Placebo

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female.
• Aged 18-55 years (both inclusive) at the time of signing informed consent.
• Body mass index (BMI) between 18.0 and 32.0 kilograms per square meter (kg/m\^2) (both inclusive) at screening.
• Body weight above 40.0 kg at screening.
• Considered to be generally healthy based on the medical history, physical examination and the results of vital signs, electrocardiogram (ECG) and clinical laboratory tests performed during the screening visit, as judged by the investigator.

You may not qualify if:

• Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using adequate contraceptive methods, as defined in Appendix 4, Section 10.4.
• Current participation (i.e., signed informed consent) in any other interventional clinical study.
• Exposure to an investigational medicinal product within 30 days or 5 half-lives of the investigational medicinal product (IMP) (if known), whichever is longer, before screening.
• Any condition which in the investigator's opinion might jeopardise the participant's safety or compliance with the protocol.
• Second or 3rd degree atrioventricular-block, prolongation of the QRS complex over 120 milliseconds (ms)., or of the corrected QT interval using the Fredericia formula (QTcF) over 450 ms for males and 470 ms for females, prominent U waves, or any other clinically significant abnormal ECG results or changes that make ECGs unsuitable for QT evaluations as judged by the investigator, at screening.
• Use of tobacco and nicotine products, defined as any of the below:
• Has used any product containing tobacco or nicotine within 90 days prior to screening.
• Unable or unwilling to refrain from the use of any product containing tobacco or nicotine throughout the study.
• Positive nicotine test at screening.
• Participant is unable to refrain from or anticipates the use of antacids, iron, or any drug known to be a moderate or strong inhibitor or inducer of uridine 5'-diphosphoglucuronosyltransferase (UGT) enzymes, cytochrome P450 (CYP) 3A4, CYP2C9 or permeability glycoprotein (P-gp), including St. John's Wort, for 28 days prior to dosing and throughout the study (Section 6.8).
• Participant is unable to refrain from or anticipate the use of any medications or substances prohibited in the study (Sections 5.3, 5.5 and 6.8).
• A minimum of 20% African-American participants will be included in each part of this study.
• Efforts will be made to include at least 40 percentage (%) of each sex into each part of the study.

Sponsors & Collaborators

• Novo Nordisk A/S: lead

Study Sites (1)

PAREXEL Intl - EPCU-Baltimore

Baltimore, Maryland, 21225, United States

Location

MeSH Terms

Conditions

Anemia, Sickle Cell; Thalassemia

Interventions

Moxifloxacin

Condition Hierarchy (Ancestors)

Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Fluoroquinolones; 4-Quinolones; Quinolones; Quinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Officials

• Clinical Transparency (dept. 2834)

  Novo Nordisk A/S

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2025
• First Posted: June 15, 2025
• Study Start: June 9, 2025
• Primary Completion: September 12, 2025
• Study Completion: September 22, 2025
• Last Updated: January 2, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

US (1)