COMPARISON OF PLAIN BLOCKS FOR POSTOPERATIVE PAIN MANAGEMENT IN GYNECOLOGICAL ABDOMINAL SURGERIES

NCT07021105 | Enrolling By Invitation

• 1 other identifier: Decision No. 145
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study compares the effects of transversus abdominis plane (TAP) block, quadratus lumborum block (QLB), and erector spinae plane block (ESP) on postoperative morphine consumption, pain scores, patient satisfaction, and side effects in patients undergoing gynecological abdominal laparotomy surgeries.

Conditions

Surgery With General Anesthesia; Gynecologic Surgical Procedures; Plane Block; Postoperative Pain Management

Keywords

Gynecologic surgery; Transversus abdominis plane block; Erector spinae plaen block; Quadratus lumborum block; morphine consumption

Outcome Measures

Primary Outcomes (1)

• morphine consumption in the postoperative period

  Thus the primary aim of this study was to assess the morphine consumption in the postoperative period

  For postoperative 24 hours

Secondary Outcomes (1)

• pain score (VAS=0-10), patient satisfaction (0-10), the need for rescue analgesia (mg) and side effects

  For postoperative 24 hours

Study Arms (4)

Group E

ACTIVE COMPARATOR

Group ESP \& QLB, TAP, Control

Procedure: QLB plane block; Procedure: TAP Block; Other: No intervention

Group Q

ACTIVE COMPARATOR

Group QLB \& ESP, TAP, Control

Procedure: ESP Plane block; Procedure: TAP Block; Other: No intervention

Group T

ACTIVE COMPARATOR

Group T \& ESP, QLB, Control

Procedure: ESP Plane block; Procedure: QLB plane block; Other: No intervention

Group C

NO INTERVENTION

Group C \& ESP, QLB, TAP

Interventions

ESP Plane block PROCEDURE

Group E (n=20): Bilateral erector spinae plane (ESP) block will be performed with 40 ml of 0.25% bupivacaine (20 ml on each side) at the T12 level, approximately 3-4 cm laterally from the midline, in the neurofascial plane between the transverse processes and the erector spinae muscle.

Group Q; Group T

QLB plane block PROCEDURE

Group Q (n=20): Bilateral quadratus lumborum block (QLB) will be performed with 40 ml of 0.25% bupivacaine (20 ml on each side), placed between the psoas major and quadratus lumborum muscles under US guidance, between the iliac crest and the 12th rib.

Group E; Group T

TAP Block PROCEDURE

Group T (n=20): Bilateral transversus abdominis plane (TAP) block will be performed with 40 ml of 0.25% bupivacaine (20 ml on each side) in the neurofascial plane between the internal oblique and transversus abdominis muscles.

Group E; Group Q

No intervention OTHER

Group C (Control group, n=20): No block will be applied, only the standard intravenous patient-controlled analgesia (PCA) protocol will be used.

Group E; Group Q; Group T

Eligibility Criteria

• Age: 18 Years - 69 Years
• Gender Eligibility Details: 80 patients aged between 18 and 69 years, with ASA 1-2 score (mild anemia, hypertension, diabetes, obesity, etc.), who were scheduled to undergo major gynecological abdominal surgery
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged between 18 and 69 years, with ASA 1-2 score scheduled to undergo major gynecological abdominal surgery

You may not qualify if:

• ASA score 3 or above, patients younger than 18 or older than 69 years, patients with bleeding disorders or using anticoagulants, patients with a body mass index over 40, patients with known allergies to any drugs used in the study, and patients who could not or did not wish to use Patient-Controlled Analgesia (PCA) device

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (1)

Cukurova University

Adana, Sarıçam, 01330, Turkey (Türkiye)

Location

Related Links

• Related Info

Study Officials

• Hakkı Ünlügenç, Professör

  Cukurova University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof Dr

Model Details: Patients will be randomly assigned into four groups using a computer-generated randomization method. According to group allocation, patients will receive the following interventions before extubation under ultrasound (US) guidance except control group. Group E (n=20): Bilateral erector spinae plane (ESP) block Group Q (n=20): Bilateral quadratus lumborum block (QLB) Group T (n=20): Bilateral transversus abdominis plane (TAP) block Group C (Control group, n=20): No block will be applied

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: June 13, 2025
• Study Start: December 6, 2024
• Primary Completion: August 11, 2025
• Study Completion: September 10, 2025
• Last Updated: June 13, 2025

Record last verified: 2025-06

Locations

TU (1)