Serratus Posterior Superior Intekcostal Plane Block vs Serratus Anterior Plane Block for Postoperative Analgesia in VATS: A Randomized Trial"

NCT07020624 | Not Yet Recruiting

• 1 other identifier: SPSIPB
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Thoracotomy is known as one of the most painful surgical procedures, with up to 65% of patients developing chronic post-thoracotomy pain syndrome (PTPS), and approximately 10% experiencing pain that significantly impacts quality of life. Video-assisted thoracoscopic surgery (VATS) has become increasingly common over the past decade and offers reduced postoperative pain, morbidity, and length of hospital stay compared to open thoracotomy. However, VATS can still cause moderate to severe postoperative pain and a high risk of chronic pain. Optimizing analgesia after VATS remains critical. With advances in ultrasound technology, several regional anesthesia techniques such as serratus anterior plane block (SAPB), erector spinae plane block (ESPB), and thoracic epidural analgesia (TEA) have shown comparable efficacy. In 2023, Tulgar et al. described the serratus posterior superior intercostal plane block (SPSIPB), which demonstrated dermatomal coverage from C3 to T10. This randomized controlled trial aims to compare the analgesic efficacy of SPSIPB and SAPB in patients undergoing VATS procedures.

Conditions

Video Assisted Thoracoscopic Surgery; Postoperative Analgesia

Keywords

serratus posterior superior intercostal plane block; Video-assisted thoracoscopic surgery; serratus anterior plane block

Outcome Measures

Primary Outcomes (1)

• Morphine consumption in the first 24 hours postoperatively

  Morfin consumption in the first 24 hours after surgery

  up to 24 hours

Secondary Outcomes (4)

• Pain density

  up to 24 hours.

• Quality of recovery

  24 hours after surgery

• Nausea and vomiting

  up to 24 hours

• shoulder pain

  up to 24 hours

Study Arms (2)

group serratus anterior plane block (SAP)

ACTIVE COMPARATOR

At the end of the surgery, ultrasound-guided serratus anterior plane block is performed with 0.25% bupivacaine. Perioperative and postoperative routine analgesic protocol is applied (consisting of intravenous analgesics and intravenous patient-controlled analgesia) without additional intervention (block) Standard Pain Monitoring and Follow-up is performed

Other: SAPB

group serratus posterior superior intercostal plane block(SPSIP)

ACTIVE COMPARATOR

At the end of the surgery, ultrasound-guided serratus posterior superior intercostal plane block is performed with 0.25% bupivacaine. Perioperative and postoperative routine analgesic protocol is applied (consisting of intravenous analgesics and intravenous patient-controlled analgesia) without additional intervention (block) Standard Pain Monitoring and Follow-up is performed

Other: SPSIPB

Interventions

SAPB OTHER

Ultrasound guided serratus anterior plane block will be performed.

group serratus anterior plane block (SAP)

SPSIPB OTHER

Ultrasound guided serratus posterior superior intercostal plane block will be performed.

group serratus posterior superior intercostal plane block(SPSIP)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI \< 35 kg/m² Patients with ASA scores I, II, III

You may not qualify if:

• Patients who do not want to be included in the study Psychiatric and neurological disease with blurred consciousness Patients with ASA \> 3 BMI \> 35 kg/m² Abnormality in coagulation parameters History of allergy to local anesthetic drugs Infection at the injection site Patients whose surgical procedure time exceeds 150 minutes

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun University,

Samsun, Ilkadım, 55100, Turkey (Türkiye)

Location

Study Officials

• hamiyet şenol çakmak, specialist

  samsun university Samsun Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

gamze ertaş, specialist

CONTACT

5056587914; gamzertas.md@hotmail.com

hamiyet şenol çakmak, specialist

CONTACT

3623111500; hamiyetsenolcakmak@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: The anesthetist who will perform the blocks will not participate in the pain follow-up of the patients. Postoperative pain assessment and data collection will be performed by another anesthetist blinded to the study.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: two interventional group

Study Record Dates

• First Submitted: May 22, 2025
• First Posted: June 13, 2025
• Study Start: July 1, 2025
• Primary Completion: January 15, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: June 13, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)