Monitoring Arm Recovery After Stroke (MARS)

NCT07016295 | Recruiting

• 1 other identifier: LRS/RGO-24/25-47508
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

People who have a stroke often find it hard to do the things they did before. This can be caused by problems with arm movement. One in five people do not get any arm movement back after a stroke. Arm movements can be measured accurately in a laboratory, but it is very expensive and not easy to do in hospital. That means it is hard to tell if the arm is recovering to move like it did before the stroke or adapting to perform tasks in other ways. To tell if a treatment is working, the investigators are making a phone app to record arm movement, using the camera. The recordings will be turned into data showing movement difficulties and sent to hospital records for clinicians. Clinicians will see if movement changes, to help choose the best treatment. The investigators are looking for twelve stroke survivors to help test this app.

• The session will be at King's College London, on Guy's Campus.
• It will run for 2-3 hours.
• Participants will wear a vest or tight-fitting clothes.
• The investigators will place non-invasive markers on the participants arm.
• The investigators will video simple movements such as drinking from a cup.
• The investigators will also measure the same simple movements using the laboratory cameras. This will show us if our app can measure arm movement as well as laboratory tests. If they do, the investigators will know the app is accurate. In future this technology can improve recovery by correcting stroke survivors when they perform home exercises.

Conditions

Stroke

Keywords

biomechanics; pose estimation models; upper limb

Outcome Measures

Primary Outcomes (1)

• Pose estimation model accuracy

  Agreement between pose estimation and biomechanics measurements

  During intervention

Secondary Outcomes (5)

• Fugl-Meyer Upper limb Assessment

  baseline, before intervention

• Motricity Index

  baseline, before intervention

• Cancellation OCS

  baseline, before intervention

• Box and block

  during the intervention

• ARAT-2

  during the intervention

Study Arms (2)

Stroke survivors

Behavioral: Biomechanical analysis of arm movement; Behavioral: Pose estimation of arm movement

Healthy age-matched controls

Behavioral: Biomechanical analysis of arm movement; Behavioral: Pose estimation of arm movement

Interventions

Biomechanical analysis of arm movement BEHAVIORAL

Marker based kinematic analysis

Healthy age-matched controls; Stroke survivors

Pose estimation of arm movement BEHAVIORAL

Marker free kinematic analysis

Healthy age-matched controls; Stroke survivors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

18 stroke survivors 8 Healthy age-matched controls

You may qualify if:

• History of stroke
• Arm impairment evidenced by Fugl-Meyer Upper Limb Assessment between 9-60/66.

You may not qualify if:

• Severe cognitive impairment preventing ability to consent to treatment and understand and follow research protocol
• Severe language deficit preventing ability to consent to treatment and understand and follow research protocol
• Shoulder pain \>3/10 on visual analog scale
• Unable to maintain independent sitting balance without a high back support.
• Wheelchair users that are unable to transfer with assistance of 1 to lab chair or whose wheelchair backrest cannot colapse.

Sponsors & Collaborators

• King's College London: lead
• King's College Hospital NHS Trust: collaborator

Study Sites (1)

Centre for Human and Applied Physiological Sciences

London, SE1 1UL, United Kingdom

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Vasa Curcin, PhD

  King's College London

  STUDY CHAIR

Central Study Contacts

Ulrike Hammerbeck, PhD

CONTACT

+44 (0) 20 7888 6292; ulrike.hammerbeck@kcl.ac.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 11, 2025
• Study Start: July 28, 2025
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): April 30, 2027
• Last Updated: August 11, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)