The Behavioral Therapy for Primary Monosymptomatic Nocturnal Enuresis

NCT07015320 | Completed DMC

• 1 other identifier: R408
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

A prospective randomized clinical study was conducted at Urology departments, faculties of medicine, Fayoum and Cairo Universities. All children either boys or girls between 4-4.5 years old presented with bedtime wetting despite good daytime urine control were included in the study. The children who were older than 4.5 years, had daytime voiding dysfunction, had !، behavioural disorders like attention deficient and hyperactivity disorder (ADHD) or other comorbidities like diabetes mellitus (DM) or congenital abnormalities were excluded from the study. In addition, those children whom parents refused to sign the consent of participation were also excluded. 120 children with primary monosymptomatic nocturnal enuresis (PMNE) were initially included in this study and randomized into two groups according to computer generated randomization. Group A (early therapy) included initially 60 child who had done behavioural and alarm therapy from the start of the study regularly till the age of 5.5 years and Group B (deferred therapy) included 60 child who waited without therapy till age of 5 years, then they started the behavioural and alarm therapy regularly for 6 months. They were interviewed at urology clinics in Fayoum and Cairo Universities in Egypt. The behavioural therapy was in the form of prompted and scheduled voiding, regular sleep timing, fluid and caffeine restriction and avoiding the cellular phones 2 hours before bedtime. If the child had constipation, it should be treated. In addition, alarm therapy was performed in the form of awaking the child every night by his parents after 1-2 hours from deep sleep to void then continue the sleep. The parents should be informed about the importance of their psychological support I to their child by avoiding any punishment or embarrassment. Furthermore, the parents were asked to monitor their child's response by documenting the number of wet nights within the last 4 month. All children were then evaluated at the age of 5 and 5.5 years using the following outcomes through the last month before the visit: complete response (0 wet nights), \> 80 % stoppage of bedwetting (\< 6 wet nights), 50-80 % stoppage of bedwetting (6-15 wet nights) and \< 50 % stoppage of bedwetting (\> 15 wet nights).

Conditions

Enuresis, Nocturnal

Keywords

nocturnal enuresis; behavioural therapy; urotherapy

Outcome Measures

Primary Outcomes (1)

• bed wetting

  complete response (0 wet nights), \> 80 % stoppage of bedwetting (\< 6 wet nights), 50-80 % stoppage of bedwetting (6-15 wet nights) and \< 50 % stoppage of bedwetting (\> 15 wet nights).

  6 months

Study Arms (2)

urotherapy

Behavioral: urotherapy

control

Behavioral: no intervention

Interventions

urotherapy BEHAVIORAL

prompted and scheduled voiding, regular sleep timing, fluid and caffeine restriction and avoiding the cellular phones 2 hours before bedtime. If the child had constipation, it should be treated. In addition, alarm therapy was performed in the form of awaking the child every night by his parents after 1-2 hours from deep sleep to void then continue the sleep. The parents should be informed about the importance of their psychological support to their child by avoiding any punishment or embarrassment. Furthermore, the parents were asked to monitor their child's response by documenting the number of wet nights within the last month

urotherapy

no intervention BEHAVIORAL

no intervention

control

Eligibility Criteria

• Age: 4 Years - 5 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

PMNE

You may qualify if:

• PMNE

You may not qualify if:

• neurogenic bladder

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Giza, Egypt

Location

MeSH Terms

Conditions

Nocturnal Enuresis

Condition Hierarchy (Ancestors)

Enuresis; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Behavioral Symptoms; Behavior; Elimination Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 11, 2025
• Study Start: January 15, 2023
• Primary Completion: December 30, 2024
• Study Completion: December 30, 2024
• Last Updated: June 11, 2025

Record last verified: 2023-01

Locations

EG (1)