Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis

NCT07012434 | Not Yet Recruiting

• 1 other identifier: SPPH2025381
• Study Type: observational
• Target: 133
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study looks at memory problems after surgery in people with liver disease. We want to know how often these problems happen and what might cause them. The main question it aims to answer is:

• Adults getting stomach surgery
• Both people with and without liver disease What participants will do:
• Take memory tests before and after surgery
• Give stool (poop) and blood samples before and after surgery Why this matters: Memory problems after surgery can make recovery harder. If we find that stomach bacteria or body chemicals are involved, doctors might find new ways to prevent these problems in people with liver disease.

Conditions

Liver Cirrhosis

Keywords

Postoperative delirium; gut microbiota dysbiosis; metabolomics

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative delirium within 7 days after upper abdominal surgery in patients with liver cirrhosis.

  within 7 days after sugery

Secondary Outcomes (1)

• The incidence of postoperative delirium within 7 days after upper abdominal surgery in patients without liver cirrhosis.

  within 7 days after sugery

Study Arms (2)

Patients with liver cirrhosis scheduled for upper abdominal surgery

Patients without liver cirrhosis scheduled for upper abdominal surgery

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospitalized patients scheduled for surgical treatment at Sichuan Provincial People's Hospital.

You may qualify if:

• Age: 18-80 years
• Patients with or without liver cirrhosis scheduled for upper abdominal surgery due to various clinical indications
• Ability to comply with the study protocol and provide informed consent

You may not qualify if:

• Comorbid severe cardiac, pulmonary, or renal diseases
• Patients with mental status incompatible with study participation, including:
• Psychiatric disorders
• Inability to communicate clearly
• Any condition preventing effective communication or cooperation

Sponsors & Collaborators

• Sichuan Provincial People's Hospital: lead

Biospecimen

Retention: SAMPLES WITH DNA

Serum and anal swab

MeSH Terms

Conditions

Liver Cirrhosis; Emergence Delirium

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Peng Li, MD

CONTACT

86+13668169590; lipengmazui@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director, Anesthesia and Surgery Center

Study Record Dates

• First Submitted: June 2, 2025
• First Posted: June 10, 2025
• Study Start: June 15, 2025
• Primary Completion: September 1, 2025
• Study Completion: October 30, 2025
• Last Updated: June 10, 2025

Record last verified: 2025-06