Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital

NCT06924294 | Not Yet Recruiting DMC

• 1 other identifier: liver cirrhosis
• Study Type: observational
• Target: 290
• Locations: 1 country
• Sites: 1

Brief Summary

• To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients.
• To evaluate the short-term outcomes of those patients.

Conditions

Liver Cirrhosis

Keywords

renal affection in patients with liver cirrhosis

Outcome Measures

Primary Outcomes (2)

• In-hospital mortality

  Mortality during hospital stay

  Through the study completion , average 6 months

• Phenotypes of acute kidney injury across geographic areas

  Characteristics of acute kidney injury (clinical type and stage)

  Baseline ( at admission ), then through the study completion, average 6 months

Secondary Outcomes (3)

• 28-day mortality

  28 days

• Resolution of AKI

  Hospital stay (up to 90 days)

• Development of CKD

  90 days

Study Arms (1)

liver cirrhosis admitted to Al-Rajhi liver hospital

observation of renal affection in patients known to have liver cirrhosis

Other: observation of renal affection in patients with liver cirrhosis

Interventions

observation of renal affection in patients with liver cirrhosis OTHER

* CBC * Liver function test * kidney function test (serum creatinine, BUN, eGFR (EPI equation and MDRD equation) , * Prothrombin time and concentration, INR, * Serum electrolytes * Urine analysis.

liver cirrhosis admitted to Al-Rajhi liver hospital

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with liver cirrhosis admitted to the department .

You may qualify if:

• Patients with liver cirrhosis admitted to the department .

You may not qualify if:

• Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR \<60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
• Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Al-Raghi liver hospital

Asyut, Assuit, Egypt

Location

Related Publications (2)

• Choi YJ, Kim JH, Koo JK, Lee CI, Lee JY, Yang JH, Ko SY, Choe WH, Kwon SY, Lee CH. Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal. Clin Mol Hepatol. 2014 Jun;20(2):185-91. doi: 10.3350/cmh.2014.20.2.185. Epub 2014 Jun 30.

  PMID: 25032185 BACKGROUND

• Duah A, Nkrumah KN. Prevalence and predictors for spontaneous bacterial peritonitis in cirrhotic patients with ascites admitted at medical block in Korle-Bu Teaching Hospital, Ghana. Pan Afr Med J. 2019 May 16;33:35. doi: 10.11604/pamj.2019.33.35.18029. eCollection 2019.

  PMID: 31384350 BACKGROUND

Related Links

• https://scholar.google.com/scholar\_lookup?journal=Clinical%20and%20Molecular%20Hepatology\&title=Prevalence%20of%20renal%20dysfunction%20in%20patients%20with%20cirrhosis%20according%20to%20ADQI-IAC%20working%20party%20proposal\&author=Y.%20J.%20Choi\&author

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohamed Omar Abd El-Malek, professor

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Mohamed Omar Abd El-Malek, professor

CONTACT

0201007343214; Omar7619@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: April 11, 2025
• Study Start: June 1, 2025
• Primary Completion: November 30, 2025
• Study Completion: December 31, 2025
• Last Updated: April 27, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)