NCT07010978

Brief Summary

The goal of this pilot randomized clinical trial is to prepare for a larger randomized clinical trial (RCT) and collect some early data to learn if the intervention can help people who use medications for opioid use disorder (MOUD). The main questions it aims to answer are:

  1. 1.Is it feasible to recruit and randomize people to both treatment groups?
  2. 2.Does linking people to recovery community centers lead to better recovery outcomes?

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
128

participants targeted

Target at P50-P75 for not_applicable

Timeline
11mo left

Started Aug 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress46%
Aug 2025Apr 2027

First Submitted

Initial submission to the registry

May 30, 2025

Completed
9 days until next milestone

First Posted

Study publicly available on registry

June 8, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

August 20, 2025

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2026

Expected
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 15, 2027

Last Updated

September 26, 2025

Status Verified

July 1, 2025

Enrollment Period

1 year

First QC Date

May 30, 2025

Last Update Submit

September 23, 2025

Conditions

Keywords

opioid use disordermoudmedications for opioid use disorderrecoveryrecovery community centers

Outcome Measures

Primary Outcomes (1)

  • Recruitment Rate

    The recruitment rate will be estimated from the number of study participants enrolled per month; this information will be used for planning a subsequent R01, in line with the goals of the R34 mechanism used to fund this study. The recruitment rate will be reported as mean with standard deviation (based on monthly observations) and will be reported descriptively.

    Baseline

Secondary Outcomes (4)

  • Study Withdrawals

    1 month

  • Completion of Recovery Activities

    1 month

  • Completion of Follow-up Surveys

    Baseline, 1, 3, 6, and 12 month

  • Completion of Timeline Follow-Back (TLFB) Interviews

    Baseline, 1, 3, 6, and 12 months

Other Outcomes (7)

  • The Substance Use Recovery Evaluator (SURE)

    Baseline, 1, 3, 6, and 12 months

  • Brief Measure of Recovery (based on SAMHSA's definition of recovery)

    Baseline, 1, 3, 6, and 12 months

  • Experience of Support (Based on SAMHSA's definition of peer support)

    Baseline, 1, 3, 6, and 12 months

  • +4 more other outcomes

Study Arms (2)

Recovery Community Center (RCC) Linkage

EXPERIMENTAL

These participants will be assigned to visit their local recovery community center at least twice, on two different days, within the first month of the study and to report on their RCC visits.

Behavioral: Recovery Community Center Participation

Enhanced Treatment as Usual (ETAU)

ACTIVE COMPARATOR

These participants will be asked to complete any recovery activity of their choosing at least twice, on two different days, within the first month of the study and to report on their chosen recovery activities.

Behavioral: Enhance Treatment as Usual

Interventions

Recovery community centers are brick and mortar buildings that house recovery-oriented organizations, located in the heart of their communities. They act as recovery hubs, offering a variety of recovery support services in house as well as connecting participants to resources in their area. They are peer-led organizations that are open to anyone in early or long-term recovery from substance use and that recognize that there are multiple pathways to recovery. Study participants will be provided with information about their local RCC (including a video link, contact information, a monthly calendar of events, a list of services and activities offered by the RCC, transportation options, etc.) and will be asked to visit the RCC on two different occasions within one month of enrollment.

Recovery Community Center (RCC) Linkage

In this study, the enhanced treatment as usual intervention will encompass providing participants with information about diverse recovery activities (e.g., mutual help group meetings, exercise, job search, recovery coach meetings, etc.) and then to assign participants to complete a recovery activity of their choosing one two different days within one month after enrollment. Participants can do the same activity twice, or different activities on each of the two days assigned.

Enhanced Treatment as Usual (ETAU)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • + years of age
  • Uses MOUD (at enrollment; participants may stop using MOUD subsequently) to treat OUD
  • Receives MOUD from a clinic/pharmacy located within 15 miles of an RCC vetted by our study team, which serves a Black community (i.e., defined as being located in a ZIP code where ≥27% of the residents are Black, as per US Census)
  • Is willing and able to engage in study procedures (i.e., online surveys, timeline follow back interview)
  • Is willing to be randomized

You may not qualify if:

  • \- Has visited a vetted RCC during the past 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

MeSH Terms

Conditions

Opioid-Related Disorders

Condition Hierarchy (Ancestors)

Narcotic-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Study Officials

  • Bettina Hoeppner, Ph.D., M.S.

    Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Bettina Hoeppner, Ph.D., M.S.

CONTACT

Susanne Hoeppner, PhD, MApStat

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Model Details: remote, randomized clinical trial
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle Investigator

Study Record Dates

First Submitted

May 30, 2025

First Posted

June 8, 2025

Study Start

August 20, 2025

Primary Completion (Estimated)

August 31, 2026

Study Completion (Estimated)

April 15, 2027

Last Updated

September 26, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will share

The investigators will provide de-identified IPD related to the aims, baseline demographics, and outcomes described in this study record to interested individuals one year following achievement of the aims of the project (i.e., publication of the main outcome papers). Data sharing will be contingent on meeting all institutional regulations for data use agreements and on receiving evidence of the recipient's institution's IRB approval for planned analyses of the data. The investigator team will be available to address queries.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
The investigators will provide de-identified data from this project to interested individuals for one year following achievement of the aims of the project (i.e., publication of the main outcome papers).
Access Criteria
Data sharing will be contingent on meeting all institutional regulations for data use agreements and on receiving evidence of the recipient's institution's IRB approval for planned analyses of the data. Interested parties requesting data will receive the requested data needed to execute their analysis plan in accordance with these approvals. The IPD will be provided in digital format with clear labels for all variables, will be de-identified before it is shared, and will be released directly by the investigators to the recipients with secure data transfer. Regarding supporting information, the final version of the study protocol (including the statistical analysis plan (SAP)) and the final version of the Informed Consent Form (ICF) will be made publicly available in this clinicaltrials.gov record. Additional supporting information, including analytic code, will be made available upon a specific request to the investigative team.

Locations