Effect of Music on Cue Reactivity for Patients With Opioid Use Disorder

NCT06948890 | Completed

• 1 other identifier: 2025P000151
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

This research is being performed to understand the role of music in people's opioid cravings, opioid use, and recovery. Music affects individuals in so many ways, and can trigger strong good and bad emotions. People listen when they are sad and want to feel happy, when they are with friends, when they exercise, and when they just want to pass the time. However, it is not known what role music plays in adding to or taking away cravings, and the role it has in drug use and addiction. In this study, the researchers want to learn if music can reduce cues that lead to cravings for opioids. The researchers also want to learn about subjects' relationship to music and how it contributes to drug use, recovery, and their life overall.

Conditions

Opioid Use Disorder

Keywords

opioid; opioid use disorder; methadone; buprenorphine; music; cue reactivity

Outcome Measures

Primary Outcomes (1)

• Opioid Cravings

  Subjects will rank their craving for opioids on a 100-point Visual Analog Scale before and after being shown drug-related cues (images). The primary outcome will determine if there is a difference in craving levels in the music vs. silence groups.

  on Day 1

Study Arms (2)

music

EXPERIMENTAL

In this arm, subjects will rate their cravings for opioids on a 0-100 point visual analog scale. They will then listen to 2 songs of their choosing. They will then be shown a series of images "cues" related to drug use, and will again be asked their cravings for opioids.

Other: Music intervention

silence

PLACEBO COMPARATOR

In this arm, subjects will rate their cravings for opioids on a 0-100 point visual analog scale. They will then listen to 10 minutes of silence. They will then be shown a series of images "cues" related to drug use, and will again be asked their cravings for opioids.

Other: Silence

Interventions

Music intervention OTHER

Subjects will listen to two songs of their choosing. They will be prompted: "Please choose two songs that you really enjoy and that make you feel relaxed or take away stress".

music

Silence OTHER

Subjects will listen to 10 minutes of silence through high quality noise canceling headphones

silence

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older
• Current diagnosis of opioid use disorder
• Actively receiving buprenorphine or methadone treatment with a stable dose of at least 30 days

You may not qualify if:

• Any significant impairment in mental status that would interfere with the ability to provided informed consent including suicidality, homicidality, or psychosis.
• Hearing impaired
• Vision impaired
• Patient reports that they are pregnant
• Requiring the use of any prescription opioid analgesics during the trial
• Currently prescribed naltrexone
• Chronic pain, defined as pain on the numeric rating scale (0-10) of \>3 every day for over 3 months.

Sponsors & Collaborators

• Brigham and Women's Hospital: lead

Study Sites (1)

Brigham and Women's Hospital

Boston, Massachusetts, 02459, United States

Location

Related Publications (5)

• Suzuki J, Martin B, Prostko S, Chai PR, Weiss RD. Cannabidiol Effect on Cue-Induced Craving for Individuals with Opioid Use Disorder Treated with Buprenorphine: A Small Proof-of-Concept Open-Label Study. Integr Med Rep. 2022 Aug 1;1(1):157-163. doi: 10.1089/imr.2022.0070. Epub 2022 Aug 26.

  PMID: 36105269 BACKGROUND

• Chai PR, Carreiro S, Ranney ML, Karanam K, Ahtisaari M, Edwards R, Schreiber KL, Ben-Ghaly L, Erickson TB, Boyer EW. Music as an Adjunct to Opioid-Based Analgesia. J Med Toxicol. 2017 Sep;13(3):249-254. doi: 10.1007/s13181-017-0621-9. Epub 2017 Jun 23.

  PMID: 28646359 BACKGROUND

• Chai PR, Schreiber KL, Taylor SW, Jambaulikar GD, Kikut A, Hasdianda MA, Boyer EW. The Feasibility and Acceptability of a Smartphone-Based Music Intervention for Acute Pain. Proc Annu Hawaii Int Conf Syst Sci. 2019 Jan 8;2019:3917-3925.

  PMID: 30700971 BACKGROUND

• Chai PR, Schwartz E, Hasdianda MA, Azizoddin DR, Kikut A, Jambaulikar GD, Edwards RR, Boyer EW, Schreiber KL. A Brief Music App to Address Pain in the Emergency Department: Prospective Study. J Med Internet Res. 2020 May 20;22(5):e18537. doi: 10.2196/18537.

  PMID: 32432550 BACKGROUND

• Colebaugh CA, Wilson JM, Flowers KM, Overstreet D, Wang D, Edwards RR, Chai PR, Schreiber KL. The Impact of Varied Music Applications on Pain Perception and Situational Pain Catastrophizing. J Pain. 2023 Jul;24(7):1181-1192. doi: 10.1016/j.jpain.2023.01.006. Epub 2023 Jan 14.

  PMID: 36646399 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Opioid-Related Disorders

Interventions

SIR1 protein, S cerevisiae

Condition Hierarchy (Ancestors)

Narcotic-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Scott G Weiner, MD, MPH

  Brigham and Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 20, 2025
• First Posted: April 29, 2025
• Study Start: April 20, 2025
• Primary Completion: August 28, 2025
• Study Completion: February 28, 2026
• Last Updated: March 4, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)