Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

NCT07125001 | Recruiting

• 1 other identifier: 1939453
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Mangos contain a number of nutrients that may improve gut and metabolic health. The purpose of this research is to see how eating mangos every day for 4 weeks instead of snacks high in calories and low in nutrients such as cookies, crackers, chips, and candy can impact adolescent health.

Conditions

Inflammation; Cardiometabolic Health Indicators; Vascular Function in Healthy Volunteers

Keywords

mango; cardiometabolic; adolescents; microbiome

Outcome Measures

Primary Outcomes (1)

• Microvascular Function

  Microvascular function as measured by peripheral arterial tonometry (ENDO PAT 2000)

  4 weeks

Secondary Outcomes (9)

• Cytokines

  4 weeks

• short chain fatty acids

  4 weeks

• Bile acids

  4 weeks

• zonulin

  4 weeks

• soluble lipopolysaccharide binding protein

  4 weeks

Study Arms (2)

Mango arm

EXPERIMENTAL

Ataulfo Mango intake

Other: Ataulfo mango

No mango intake

NO INTERVENTION

4 weeks of no mango intake

Interventions

Ataulfo mango OTHER

4 weeks of Ataulfo mango intake

Mango arm

Eligibility Criteria

• Age: 12 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• \- Male or Female 12-19 years old
• BMI ≥ 85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html)
• Self-reported Hispanic/Latino
• Subject is willing and able to comply with the study protocols
• Subject is willing to consume the test products
• Female-specific criteria: if menstruating, eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)
• Access to a smartphone or tablet at least 1x / day and willing to take pictures associated with the products to be consumed in the study

You may not qualify if:

• \- Reported food allergies.
• Currently taking prescription drugs, with the exception of asthma inhalers, which are allowed
• BMI \<85th percentile (https://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html)
• Current participation in a moderate or high-intensity daily exercise routine
• Self-reported disease, serious illness, or who are currently under acute medical care.
• Currently taking prescription drugs.
• Any supplement use, including multi-vitamin/ mineral, herbal, plant or botanical, fish oil, and oil supplements, and not willing to discontinue before starting the study.
• Vegetarian or vegan diet
• Self-reported malabsorption or gastrointestinal issues
• Fruit and vegetable intake exceeding daily recommendations of 5 servings
• Smoking (vaping, conventional nicotine-containing products or marijuana)
• Current enrollee in a clinical research study

Sponsors & Collaborators

• University of California, Davis: lead

Study Sites (1)

Academic Surge; Ragle Human Nutrition Research Center

Davis, California, 95616, United States

RECRUITING

MeSH Terms

Conditions

Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Roberta R Holt, PhD

  University of California, Davis

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Roberta R Holt, PhD

CONTACT

15304005952; rrholt@ucdavis.edu

Genesis G Guerra Gaitan, MS

CONTACT

gguerragaitan@ucdavis.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2025
• First Posted: August 15, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): March 31, 2028
• Study Completion (Estimated): March 31, 2028
• Last Updated: February 3, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)