Risk Assessment of Mild Traumatic Brain Injury in Military Training

NCT06992570 | Enrolling By Invitation

• 1 other identifier: SNIPER-mTBI
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The SNIPER-TBI study aims to identify and quantify the risk of mild traumatic brain injury (mTBI) in soldiers of the Czech Armed Forces during specific high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. The study will utilize both diagnostic biomarker analysis and experimental biomechanical measurements to assess the physiological impact of these activities on brain health. The ultimate goal is to reduce mTBI incidence, improve operational readiness, and extend the active service duration of soldiers through targeted preventive measures.

Conditions

Trauma, Brain

Keywords

mTBI; Biomechanics; Military Training

Outcome Measures

Primary Outcomes (4)

• Quantification of mTBI Risk 1

  Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker glial fibrillary acidic protein (GFAP) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.

  Up to 24 hours post-exposure

• Quantification of mTBI Risk 2

  Measure the severity of mTBI among soldiers engaged in high-risk training activity. Concentration of brain injury biomarker ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) in blood sample collected within 24 hours post-exposure. Measured in nanogram per milliliter.

  Up to 24 hours post-exposure

• Biomechanical Analysis of Head Impact Forces 1

  Evaluate the mechanical forces experienced by soldiers during high-risk activity using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) will be measured during training activity. Measured in meters per second squared.

  Baseline

• Biomechanical Analysis of Head Impact Forces 2

  Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Pressure wave during training activity will be analyzed. Measures in Pascal.

  Baseline

Study Arms (1)

High-Risk Military Training Exposure

EXPERIMENTAL

Active-duty soldiers participating in high-risk training activities, including parachute jumps, high-caliber firearms shooting, artillery blasts, and Close Quarters Battle (CQB) exercises. Participants will undergo real-time biomechanical measurement and biomarker analysis to assess mild traumatic brain injury (mTBI) risk. Diagnostic biomarker analysis (GFAP, UCH-L1) Real-time biomechanical monitoring (accelerometers, high-speed cameras)

Diagnostic Test: Quantification of mild trauma brain injury risk; Other: Biomechanical Analysis of Head Impact Forces

Interventions

Quantification of mild trauma brain injury risk DIAGNOSTIC_TEST

Measure the incidence and severity of mTBI among soldiers engaged in high-risk training activities. (e.g. parachute jumps, high-caliber firearms shooting, artillery fire, explosions). Concentration of brain injury biomarkers (GFAP, UCH-L1) in blood samples collected within 24 hours post-exposure

High-Risk Military Training Exposure

Biomechanical Analysis of Head Impact Forces OTHER

Evaluate the mechanical forces experienced by soldiers during high-risk activities using wearable accelerometers and high-speed video analysis. Peak head acceleration (g-force) and pressure wave analysis during training activities.

High-Risk Military Training Exposure

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-50 years
• Active-duty military personnel
• Participating in designated high-risk training activities

You may not qualify if:

• History of significant brain injury
• Current neurological disorders
• Use of anticoagulant medications

Sponsors & Collaborators

• Charles University, Czech Republic: lead
• Military University Hospital, Prague: collaborator

Study Sites (1)

Military University Hospital Prague

Prague, Czech Republic, 16902, Czechia

Location

MeSH Terms

Conditions

Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Michal Soták, M.D., Ph.D.

  Military University Hospital, Prague

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 12, 2025
• First Posted: May 28, 2025
• Study Start: November 4, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)