Responses of Adults Smoking Nondaily and Daily in the Experimental Tobacco Marketplace

NCT06988371 | Completed

• 2 other identifiers: 995965U54DA058256-02
• Study Type: interventional
• Target: 695
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this project is to learn about the potential impact of tobacco regulations that could affect the availability of tobacco products among adults who smoke nondaily and daily. Nondaily smoking is increasingly common and tobacco regulation research should consider how FDA actions may impact this group. Participants will be asked to complete online surveys and tests, online shopping sessions in a simulated Experimental Tobacco Marketplace. Reactions and decisions of adults who smoke nondaily and daily will be compared.

Conditions

Tobacco Use; Cigarette Use

Keywords

tobacco; cigarettes; nondaily smoking; behavioral economics

Outcome Measures

Primary Outcomes (2)

• Aggregate behavioral economic demand across all participants under the proposed regulatory environments

  Participants will complete trials of the Experimental Tobacco Marketplace wherein the price of a target commodity will be increased. Nonlinear mixed effects modeling will be used to fit a curve to estimate the number of products purchased at each price and the analysis will result in an measure of overall price sensitivity under each of the regulatory conditions.

  Baseline

• Aggregate behavioral economic substitution across all participants under the proposed regulatory environments

  Participants will complete trials of the Experimental Tobacco Marketplace wherein the price of alternative products will be fixed across trials and their usual product will change price. Mixed effects modeling will be used to fit a curve to estimate the slopes and intercepts of these alternative products, revealing the degree to which participants will choose to purchase each alternative product as the price of the participant's usual product increases.

  Baseline

Secondary Outcomes (2)

• Hypothetical quantity purchased in purchase tasks

  Baseline

• Delay Discounting Tasks

  Baseline

Study Arms (2)

Daily smoking

EXPERIMENTAL

Participants who smoke cigarettes every day

Behavioral: Reduced nicotine regulatory environment; Behavioral: Restriction on characterizing flavors in combustible nicotine products; Behavioral: Restriction on characterizing flavors in noncombustible nicotine products

Nondaily smoking

EXPERIMENTAL

Participants who smoke cigarettes some days but not every day in a month

Behavioral: Reduced nicotine regulatory environment; Behavioral: Restriction on characterizing flavors in combustible nicotine products; Behavioral: Restriction on characterizing flavors in noncombustible nicotine products

Interventions

Reduced nicotine regulatory environment BEHAVIORAL

In this regulatory environment, participants' usual combustible cigarette will not be available in the Experimental Tobacco Marketplace and reduced nicotine content cigarettes will be the only available combustible cigarette.

Daily smoking; Nondaily smoking

Restriction on characterizing flavors in combustible nicotine products BEHAVIORAL

In this regulatory environment, menthol and other characterizing flavors in combustible nicotine products will not be available in the Experimental Tobacco Marketplace. Tobacco- or no-flavored combustible nicotine products will be the only combustible nicotine products available.

Daily smoking; Nondaily smoking

Restriction on characterizing flavors in noncombustible nicotine products BEHAVIORAL

In this regulatory environment, menthol and other characterizing flavors in noncombustible nicotine products will not be available in the Experimental Tobacco Marketplace. Tobacco- or no-flavored noncombustible nicotine products will be the only noncombustible nicotine products available.

Daily smoking; Nondaily smoking

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 18 years old
• Consume cigarettes 4-30 days per month
• Have no plans to quit nicotine/tobacco products
• Read and understand English

Sponsors & Collaborators

• Bethany Shorey Fennell: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

University of Kentucky

Lexington, Kentucky, 40504, United States

Location

MeSH Terms

Conditions

Tobacco Use

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Bethany Shorey Fennell, PhD

  University of Kentucky

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Mixed crossover-factorial

Study Record Dates

• First Submitted: April 29, 2025
• First Posted: May 23, 2025
• Study Start: August 18, 2025
• Primary Completion: August 29, 2025
• Study Completion: August 29, 2025
• Last Updated: October 14, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)