Chronic Neck Pain and Central Sensizitation

NCT06976398 | Completed

• 1 other identifier: Karabuk-2281
• Study Type: observational
• Target: 83
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic neck pain is one of the musculoskeletal pain problems that can cause chronic disability. It is emphasised that individuals with chronic neck pain have difficulty during different activities in their daily lives, and that this problem is a very common health problem that can lead to disability. In the case of chronic neck pain, changes in the pain threshold cause central sensitisation and individuals become more sensitive to pain stimuli. This situation can affect the processing of proprioceptive information and lead to deterioration in proprioceptive perception. This situation leads to perceptual problems in body and neck awareness. Therefore, examining the relationship between the relevant parameters is important in the rehabilitation process. In this context, the aim of the study is to examine the relationship between body awareness and pain, central sensitisation, disability and proprioception in patients with chronic non-specific neck pain.

Conditions

Neck Pain

Outcome Measures

Primary Outcomes (7)

• Central sensitization

  It will be evaluated with the "Central Sensitization Scale". The scale is scored between 0-100 and 40 points and above is recorded as sensitive.

  Baseline

• Pain severity

  Pain intensity will be assessed with the Numerical Pain Scale. It is scored between 0-10 and the higher the score, the greater the pain intensity.

  Baseline

• Pain threshold

  Pain threshold will be assessed with an algometer. An increase in the applied pressure indicates a higher pain threshold.

  Baseline

• Neck disability

  Neck disability will be evaluated with the index. It varies between 0-50 points and the higher the score, the higher the disability.

  Baseline

• Proprioception

  Proprioception will be recorded as the degree of deviation with the CROM device. As the degree of deviation increases, proprioception worsens.

  Baseline

• Body awareness

  Body Awareness Questionnaire (BAF) will be used. It varies between 18-126 points and as the score decreases, awareness decreases.

  Baseline

• Neck awareness

  It will be assessed with the Fremantle Neck Awareness Questionnaire. It varies between 0-36 and as the score increases, awareness decreases.

  Baseline

Study Arms (2)

Higher sensitization

It will consist of patients who exceed the cut-off score according to the central sensitization scale score.

Normal sensitization

It will consist of patients with a central sensitization scale score lower than the cut-off score.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with chronic non-specific neck pain will be included.

You may qualify if:

• Being between the ages of 18-65
• Being diagnosed with chronic non-specific neck pain by a doctor
• Being willing to participate in the study

You may not qualify if:

• Having psychological disorders, mental disorders, cancer and severe depression
• Having a history of traumatic injury
• Having a history of primary or metastatic spinal malignancy, spinal fracture
• Having a neurological disease (Hemiplegia, Multiple Sclerosis, Parkinson's, etc.)
• Having been diagnosed with advanced osteoporosis
• Having a history of surgical intervention or acute infection in the cervical region

Sponsors & Collaborators

• Karabuk University: lead

Study Sites (1)

Karabuk University

Karabük, 78050, Turkey (Türkiye)

Location

Related Publications (3)

• van der Maas LC, Koke A, Bosscher RJ, Twisk JW, Janssen TW, Peters M. Body Awareness as an Important Target in Multidisciplinary Chronic Pain Treatment: Mediation and Subgroup Analyses. Clin J Pain. 2016 Sep;32(9):763-72. doi: 10.1097/AJP.0000000000000320.

  PMID: 26550959 BACKGROUND

• Williams DA. Phenotypic Features of Central Sensitization. J Appl Biobehav Res. 2018 Jun;23(2):e12135. doi: 10.1111/jabr.12135. Epub 2018 Jun 27.

  PMID: 30479469 BACKGROUND

• Wand BM, Catley MJ, Rabey MI, O'Sullivan PB, O'Connell NE, Smith AJ. Disrupted Self-Perception in People With Chronic Low Back Pain. Further Evaluation of the Fremantle Back Awareness Questionnaire. J Pain. 2016 Sep;17(9):1001-12. doi: 10.1016/j.jpain.2016.06.003. Epub 2016 Jun 18.

  PMID: 27327235 RESULT

MeSH Terms

Conditions

Neck Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Musa Gunes, PhD

  Karabuk University

  STUDY DIRECTOR

• Melek Turan

  Karabuk University

  PRINCIPAL INVESTIGATOR

• Duygu Çataloluk

  Karabuk University

  PRINCIPAL INVESTIGATOR

• Aydın Sinan Apaydın, PhD

  Karabuk University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, PhD

Study Record Dates

• First Submitted: May 2, 2025
• First Posted: May 16, 2025
• Study Start: May 8, 2025
• Primary Completion: September 15, 2025
• Study Completion: September 15, 2025
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)