Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health Related Quality of Life in Patients on Hemodialysis

NCT06976281 | Completed

• 1 other identifier: Alaa-02012024
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

this study was done to investigate the effect of intradialytic blood flow restriction training on functional capacity, estimated glomerular filtration rate and health related Quality of life in patients on Hemodialysis

Conditions

Blood Flow Restriction Training; Glomerular Filtration Rate; Quality of Life; Hemodialysis

Outcome Measures

Primary Outcomes (1)

• assessment of change of estimated glomerular filtration rate

  Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration Creatinine Equation (2021) as recommended by the National Kidney Foundation to assess renal function and detect deterioration.

  at baseline and after 8 weeks

Secondary Outcomes (4)

• assessment of change of Limb Occlusion Pressure

  at baseline and after 8 weeks

• assessment of change of Glucose Homeostasis

  at baseline and after 8 weeks

• assessment of change of upper limb Muscle Strength

  at baseline and after 8 weeks

• assessment of change of lower limb Muscle Strength

  at baseline and after 8 weeks

Study Arms (2)

blood flow restriction

EXPERIMENTAL

Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion Pressure. training was conducted for 2 time/weak for 2 consecutive month

Other: conventional exercise Program; Other: blood flow restriction training

conventional exercise Program

ACTIVE COMPARATOR

Included 15 chronic kidney disease patients on hemodialysis received conventional exercise program only included isometric, aerobic, and resisted exercise individualized for every patient. training was conducted for 2 time/weak for 2 consecutive month

Other: conventional exercise Program

Interventions

conventional exercise Program OTHER

Exercises include shoulder flexion, shoulder abduction, leg extension, and hand grip. Start with 1-3 sets of 12 reps at 30% of 1-repetition maximum, increasing by 10% according to patient endurance. Cycling is a 30-minute chair or bedside cycle ergometer exercise 2 time/weak for 2 consecutive months

blood flow restriction; conventional exercise Program

blood flow restriction training OTHER

Patients received the same conventional exercise program, which included isometric, aerobic, and resisted exercise individualized for every patient with blood flow restriction by 50% of limb occlusion pressure. Training will be conducted for 2 time/weak for 2 consecutive month

blood flow restriction

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• All patients were
• Both sex aged from forty to sixty years
• Stable chronic hemodialysis patient (\< 3 months)
• Participants will be deemed medically eligible by their treating physician before participation in the present study
• Free from any other disease could interfere with exercise

You may not qualify if:

• Hemodynamic instability during hemodialysis over the last month
• Neurodegenerative diseases
• Autoimmune diseases (i.e., lupus erythematosus)
• Surgery within the past 3 months
• Severe arrhythmia, angina or cerebrovascular disease
• Unstable on dialysis
• Any musculoskeletal problem interfere with exercise

Sponsors & Collaborators

• Beni-Suef University: lead

Study Sites (1)

out-patient clinic, faculty of physical therapy, beni-suef University

Banī Suwayf, Egypt

Location

MeSH Terms

Interventions

Blood Flow Restriction Therapy

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: May 9, 2025
• First Posted: May 16, 2025
• Study Start: August 1, 2024
• Primary Completion: November 15, 2024
• Study Completion: December 15, 2024
• Last Updated: May 16, 2025

Record last verified: 2025-05

Locations

EG (1)