PET/MRI/EEG Imaging Study in Epilepsy

NCT06974305 | Recruiting

• 1 other identifier: 2022P000929
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Conditions

Epilepsy

Keywords

Functional PET; FDG-PET; Functional MRI; EEG; Epilepsy; Neuroimaging; Multimodal imaging

Outcome Measures

Primary Outcomes (1)

• Image analysis

  There are no interventions in this study and thus no outcome measures. Primary goal of the study will be achieved with image analysis on the PET/MRI/EEG data.

  Image analysis to be performed after imaging sessions are complete.

Study Arms (2)

Healthy Controls

Healthy control subjects with no major medical history

Radiation: FDG-PET/fMRI/EEG imaging

Subjects with Epilepsy

Subjects diagnosed with epilepsy and with abnormal electrical activity recorded on interictal EEG.

Radiation: FDG-PET/fMRI/EEG imaging

Interventions

FDG-PET/fMRI/EEG imaging RADIATION

Subject will undergo simultaneous EEG, fMRI, and FDG-PET imaging. This includes the use of a standard injected radioactive marker used in PET imaging.

Healthy Controls; Subjects with Epilepsy

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Study populations are healthy people and people with epilepsy.

You may qualify if:

• Age 18 or older
• Diagnosed with epilepsy with abnormal interictal EEG

You may not qualify if:

• Contraindications to PET, MRI, or EEG imaging
• History of severe brain disease such as stroke and head trauma
• History of brain surgery
• History of type I or II diabetes mellitus
• Fasting plasma glucose level \>200 mg/dL
• Employed under direct supervision of the PI conducting the research
• Current use of drugs that modulate brain function
• Current or past history of major medical, neurological, or psychiatric conditions

Sponsors & Collaborators

• Massachusetts General Hospital: lead

Study Sites (1)

Athinoula A. Martinos Center

Charlestown, Massachusetts, 02129, United States

RECRUITING

MeSH Terms

Conditions

Epilepsy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Ciprian Catana, MD, PhD

  Massachusetts General Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Magdelena S Allen, BA

CONTACT

617-724-9232; mallen27@mgh.harvard.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Radiology

Study Record Dates

• First Submitted: March 12, 2024
• First Posted: May 15, 2025
• Study Start: September 21, 2023
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 23, 2026

Record last verified: 2025-05

Locations

US (1)