Internet Delivered Cognitive Rehabilitation for Mild Cognitive Impairments

NCT06973018 | Enrolling By Invitation

• 1 other identifier: Dnr 202003079
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Acquired brain injury and neurological disorders cause cognitive deficits, which in turn cause reduced participation in everyday life. Cognitive rehabilitation, where patients learn about cognition, cognitive deficits and ways to circumvent problems arising from deficits can increase participation and quality of life. ERehabCog is an internet delivered cognitive rehabilitation program intended for patients suffering mild to moderate impairments. The program consists of information and homework assignments, which take approximately 10 weeks to complete with the assistance of a therapist. Effects are evaluated through measures of everyday life participation, mood, and life satisfaction and compared with an attention training program. This study aims to contribute to the evidence base for internet delivered cognitive rehabilitation for mild to moderate cognitive impairments. Evidence based interventions are vital to use the potential of technology to the benefit of affected patients.

Conditions

Traumatic Brain Injury; Stroke; Multiple Sclerosis; Parkinsons Disease (PD); Post-COVID-19 Condition

Keywords

brain injury; cognitive rehabilitation; nervous system disorders; eHealth; self assessment

Outcome Measures

Primary Outcomes (1)

• Mayo Portland Adaptability Inventory - fourth edition (MPAI-4), Participation subscale

  Change in T-score

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

Secondary Outcomes (6)

• MPAI-4 Adaptability subscale

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

• MPAI-4 Abilities subscale

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

• MPAI-4 Total score

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

• Hospital Anxiety and Depression Scale

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

• Life Satisfaction Questionnaire (LiSat-11)

  Two weeks before intervention, at intervention start, at the end of treatment at 10 weeks, at six months post intervention ed

Other Outcomes (2)

• Patient satisfaction questionnaire

  End of treatment at 10 weeks

• Montreal Cognitive Assessment (MoCA)

  Baseline

Study Arms (2)

eRehabCog

EXPERIMENTAL

10 week (1 hour / week, 10 hours in total) internet delivered manualised cognitive rehabilitation

Behavioral: eRehabCog

CogMed QM

ACTIVE COMPARATOR

5 week (2 hours / week, 10 hours in total) internet delivered working memory training program

Behavioral: CogMed QM

Interventions

eRehabCog BEHAVIORAL

eRehabCog is a manualised internet delivered compensatory cognitive rehabilitation program (10 weeks, 1 hour per week, 10 hours in total). It is designed to improve patient self efficacy and participation in everyday life activities through compensatory strategy learning

eRehabCog

CogMed QM BEHAVIORAL

CogMed QM is an internet delivered training program (5 weeks, 2 hours per week, 10 hours in total) designed to improve patients working memory

CogMed QM

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Enrolled in community neurorehabilitation in Stockholm, Sweden
• Mild to moderate cognitive impairment as a consequence of acquired brain injury or nervous system disease
• MoCA 21 ≥
• Sufficient command of Swedish language
• Access to internet connected device and internet connection

You may not qualify if:

• Severe and enduring psychiatric or behavioural disorders (i.e Schizophrenia, substance abuse)
• Suspected or diagnosed dementia
• Homelessness or other social instability rendering access to internet unpredictable

Sponsors & Collaborators

• Aniko Bartfai: lead
• Region Stockholm: collaborator

Study Sites (1)

Danderyd Hospital

Stockholm, Stockholm County, 116 88, Sweden

Location

Related Links

• Description of eRehabCog in text and video format (Swedish)
• Description of Cogmed QM from company webpage (English and Swedish)

MeSH Terms

Conditions

Brain Injuries, Traumatic; Stroke; Multiple Sclerosis; Parkinson Disease; Brain Injuries; Nervous System Diseases

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Cerebrovascular Disorders; Vascular Diseases; Cardiovascular Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Aniko Bartfai, PhD

  Karolinska Institutet Danderyds Sjukhus (KIDS), Department of medical rehabilitation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: senior professor in neuropsychology, Karolinska Institutet

Model Details: Participating teams were randomized to either of the two intervention arms.

Study Record Dates

• First Submitted: May 7, 2025
• First Posted: May 15, 2025
• Study Start: May 2, 2021
• Primary Completion: July 1, 2025
• Study Completion (Estimated): December 31, 2027
• Last Updated: May 15, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)