Proprioceptive Fatigue Adaptation in Osteoarthritis
PROFA-OA
Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis
1 other identifier
interventional
20
0 countries
N/A
Brief Summary
This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2025
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 6, 2025
CompletedFirst Posted
Study publicly available on registry
May 14, 2025
CompletedStudy Start
First participant enrolled
June 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedMay 14, 2025
May 1, 2025
4 months
May 6, 2025
May 6, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Joint Position Sense
Passive Joint Position Sense Test: The knee joint will be passively moved to 45°, then returned to the starting position. The participant will be asked to perceive and replicate the same angle passively. The difference between the perceived and actual angles will be recorded. An isokinetic dynamometer will be used during this test. Active Joint Position Sense Test: With their eyes closed, participants will be asked to actively move their knee to 45° and then return to the starting position. They will then be asked to actively reproduce the same angle. The difference between the measured and target angles will be recorded. An isokinetic dynamometer will be used during this test.
From enrollment to the end of intervention for 10 minutes
Study Arms (2)
Healthy Control
ACTIVE COMPARATORAge- and sex-matched postmenopausal women without knee pathology. Participants will perform the same passive and active joint position sense tests as the gonarthrosis group, before and after a control fatigue protocol using the Biodex system.
Gonarthrosis Group
EXPERIMENTALPostmenopausal women aged 50-65 with Kellgren-Lawrence Grade 2-3 knee osteoarthritis. Participants will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.
Interventions
Groups will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.
Eligibility Criteria
You may qualify if:
- Female, aged 50-65
- Postmenopausal
- Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group
- No lower extremity surgery in the last 6 months
- No neuromuscular or orthopedic condition affecting the lower extremities
You may not qualify if:
- Severe balance disorders or vestibular disease
- Bilateral knee prosthesis or severe osteoporosis
- Lower extremity musculoskeletal injury in the last 6 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Kocaeli Sağlık ve Teknoloji Üniversitesilead
- Inonu Universitycollaborator
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 6, 2025
First Posted
May 14, 2025
Study Start
June 1, 2025
Primary Completion
October 1, 2025
Study Completion
December 1, 2025
Last Updated
May 14, 2025
Record last verified: 2025-05