Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation
1 other identifier
interventional
3
1 country
1
Brief Summary
The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients. The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 11, 2025
CompletedFirst Posted
Study publicly available on registry
September 5, 2025
CompletedStudy Start
First participant enrolled
October 13, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
August 30, 2026
ExpectedOctober 6, 2025
August 1, 2025
3 months
August 11, 2025
September 30, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Improvement in upper limb motor function
Upper limb motor function will be evaluated using standardized clinical scales such as the Fugl-Meyer Assessment and proprioceptive accuracy tests. 0 indicates severe movement limitation, while a score of 66 reflects normal motor function of upper limb. Participants will undergo evaluations and treatment during six visits over approximately three weeks.
6 visits over 3 weeks
Secondary Outcomes (1)
Proprioceptive accuracy
Baseline before intervention and immediately after the 30-minute training session
Study Arms (6)
Electrical stimulation cue first
EXPERIMENTALPatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order Electrical stimulation cue, Visual cue, and No cue or Electrical stimulation cue, No cue, and Visual cue.
Visual stimulation cue first
EXPERIMENTALPatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: Visual cue, Electrical stimulation cue, and No cue, or Visual cue, No cue, and Electrical stimulation cue.
No cue first
EXPERIMENTALPatients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: No cue, Electrical stimulation cue, and Visual cue, or No cue, Visual cue, and Electrical stimulation cue.
Only electrical stimulation cue
EXPERIMENTALPatients undergo one types of interventions which is the Electrical stimulation cue.
Only visual stimulation cue
EXPERIMENTALPatients undergo one types of interventions which is the Visual stimulation cue.
Only no cue
EXPERIMENTALPatients undergo one types of interventions which is the No cue.
Interventions
A single 30-minute session is provided. Electrodes are attached to the cubital fossa, and stimulation is delivered at a frequency that increases up to 70 Hz as the elbow joint approaches the target angle. Target angles are set between 0 degrees and 120 degrees, based on each participant's available range of motion determined during the initial assessment. Participants adjust their elbow joint angle to match the provided target angle using feedback from the electrical stimulation. When the elbow joint angle matches the target angle, the maximum frequency is applied to the cubital fossa. Participants match their elbow joint angle to the target angle based on the given frequency.
A single 30-minute session is provided. The difference between the current elbow joint angle and the pre-set target angle is displayed on a screen using two colored needles (a red needle for the target angle and a black needle for the current elbow joint angle). The target angle is set within each participant's available range of motion based on the initial assessment. Participants continue the intervention by adjusting their elbow angle using the visual feedback. When the elbow joint angle matches the target angle, the two needles overlap. Based on this visual cue, participants adjust their elbow joint angle to match the target angle.
A single 30-minute session is provided. The target angle is determined within each participant's available range of motion based on the initial assessment. Throughout the session, participants receive verbal feedback from the assessor and adjust their elbow joint angle accordingly to match the target angle.
Eligibility Criteria
You may qualify if:
- Diagnosed with ischemic or hemorrhagic stroke
- Stroke confirmed by CT or MRI
- Stroke patients with proprioceptive sensory deficits
- Chronic stroke patients with onset at least 3 months prior
- Able to voluntarily flex and extend the elbow joint
- Age 19 years or older
- Provide written informed consent (participant or legal representative)
You may not qualify if:
- Severe pain during elbow joint movement
- Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
- Progressive or unstable stroke
- Presence of unilateral neglect
- Coexisting severe neurological disorders
- Major psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia Presence of a pacemaker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shinchon Severance Rehabilitation Hospital
Seoul, Seoul, 03722, South Korea
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate professor
Study Record Dates
First Submitted
August 11, 2025
First Posted
September 5, 2025
Study Start
October 13, 2025
Primary Completion
December 31, 2025
Study Completion (Estimated)
August 30, 2026
Last Updated
October 6, 2025
Record last verified: 2025-08
Data Sharing
- IPD Sharing
- Will not share