Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars

NCT06971055 | Not Yet Recruiting

• 1 other identifier: Moringa vs Sodium Hypochlorite
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric patients. The study will assess bacterial reduction using blood agar

Conditions

Dental Caries; Pulp Necrosis; Primary Tooth Pulpectomy; Pediatric Dentistry; Endodontic Infection

Keywords

Moringa oleifera; Sodium hypochlorite; Root canal irrigants; Pulpectomy; Primary molars; Enterococcus faecalis; Antimicrobial efficacy; Pediatric endodontics; Coagulase-Negative Staphylococci

Outcome Measures

Primary Outcomes (1)

• Zone of inhibition against Coagulase-Negative Staphylococci

  "Primary Outcome: The antimicrobial efficacy of both types of irrigants... based on the diameter of the zone of inhibition

  "Day 1 (Pre- and post-irrigation samples collected during the same visit)"

Study Arms (2)

Sodium Hypochlorite Group

EXPERIMENTAL

Participants in this group will receive root canal irrigation using sodium hypochlorite during pulpectomy of nonvital primary molars. A 3 mL solution will be used per canal following standard clinical procedures.

Drug: Sodium hypochlorite

Moringa oleifera Leaf Extract Group

EXPERIMENTAL

extract of Moringa oleifera leaves prepared as a solution, used as a natural antimicrobial root canal irrigant.

Biological: Moringa Oleifera Leaf Extract

Interventions

Sodium hypochlorite DRUG

sodium hypochlorite solution will be used as a root canal irrigant during pulpectomy in primary molars. A volume of 3 mL will be delivered into each canal using a syringe with a side-vented needle. Irrigation will be followed by microbial sampling for blood agar

Sodium Hypochlorite Group

Moringa Oleifera Leaf Extract BIOLOGICAL

extract of Moringa oleifera leaves will be used as an intracanal irrigant during pulpectomy. A volume of 3 mL will be used per canal, and post-irrigation microbial samples will be analyzed using the same methods as the control group.

Moringa oleifera Leaf Extract Group

Eligibility Criteria

• Age: 4 Years - 7 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children aged 4 to 7 years
• Clinically and radiographically diagnosed with nonvital primary molars requiring pulpectomy
• Cooperative children who can undergo dental treatment
• Healthy-appearing children with no systemic, physical, or mental disorders

You may not qualify if:

• Medically compromised or uncooperative children
• Primary molars indicated for extraction due to:
• Advanced root resorption (more than two-thirds)
• Teeth near exfoliation
• Deep subgingival caries preventing proper restoration
• Excessive mobility (Miller's Grade 2 or higher)

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University

Cairo, Egypt

Location

MeSH Terms

Conditions

Dental Caries; Dental Pulp Necrosis

Interventions

Sodium Hypochlorite

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases; Dental Pulp Diseases; Necrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hypochlorous Acid; Chlorine Compounds; Inorganic Chemicals; Oxides; Oxygen Compounds; Sodium Compounds

Central Study Contacts

Alawi Taha Alaidarous T Principal Investigator, BDS

CONTACT

+966500969988; al-alawi.ta@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 2, 2025
• First Posted: May 14, 2025
• Study Start: July 20, 2025
• Primary Completion: September 15, 2025
• Study Completion: January 1, 2026
• Last Updated: June 3, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)