The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
Analysis of the Relationship Between the Concentration of the Brain Derived Neurotrophic Factor (BDNF) in Plasma, the Occurrence of BDNF Gene Polymorphism (Val66Met) and White Blood Cell Markers and the Incidence of Postoperative Central Nervous System Disorders in Patients Undergoing General Anesthesia for Cardiac Surgery With Extracorporeal Circulation
1 other identifier
observational
107
1 country
1
Brief Summary
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2024
CompletedFirst Submitted
Initial submission to the registry
May 4, 2025
CompletedFirst Posted
Study publicly available on registry
May 13, 2025
CompletedMay 15, 2025
May 1, 2025
2 years
May 4, 2025
May 12, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
The main aim of the study will be to assess the correlation between brain function disorders, defined as abnormal BDNF levels, and postoperative delirium.
Up to a year after the procedure.
Eligibility Criteria
A prospective observational cohort study will recruit 200 patients scheduled for planned coronary artery bypass grafting (CABG), with the use of cardio-pulmonary by-pass who will be operated at the Cardiac Surgery Department of the Pomeranian Medical University in Szczecin. The Cardiac Surgery Department of Pomeranian Medical University has a volume of 900-1100 operations per year, 70% being CABG (approx. 700 CABG operations per year).
You may qualify if:
- Age \> 18 years.
- Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
- Ability to understand and sign an informed consent form.
You may not qualify if:
- Emergency surgery.
- Previous known cognitive disorders: Mini Mental State Examination (MMSE) score \<15.
- Baseline delirium (positive CAM test prior to surgery).
- Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
- Inability to understand Polish language.
- Inability to give and sign informed consent due to auditory or visual dysfunction.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Uniwersytecki Szpital Kliniczny nr 2 PUM w Szczecinie
Szczecin, West Pomeranian Voivodeship, 70-111, Poland
Biospecimen
whole blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD student
Study Record Dates
First Submitted
May 4, 2025
First Posted
May 13, 2025
Study Start
July 1, 2021
Primary Completion
July 1, 2023
Study Completion
July 1, 2024
Last Updated
May 15, 2025
Record last verified: 2025-05