Incidence and Risk Factors of Surgical Site Infections After Coronary Artery Bypass Grafting Surgery

NCT07130422 | Completed

• 1 other identifier: 588(6-11)E2.079/080
• Study Type: observational
• Target: 89
• Locations: 1 country
• Sites: 1

Brief Summary

The burden of coronary artery disease (CAD) is increasing in the Nepalese population. Coronary artery bypass grafting (CABG) remains one of the most frequently performed surgical interventions for the management of advanced CAD. Despite this, there is a paucity of data regarding the incidence and determinants of surgical site infections (SSIs) following CABG in the Nepalese context. This study aimed to determine the incidence of SSIs after CABG surgery in the Nepalese population.

Conditions

CABG

Outcome Measures

Primary Outcomes (1)

• Incidence of Surgical Site Infection (SSI) Following Coronary Artery Bypass Grafting (CABG)

  The study aims to assess the proportion of patients developing surgical site infections within the first 30 days after undergoing coronary artery bypass graft surgery. SSIs will be identified based on standardized diagnostic criteria, and cases will be classified according to infection depth and site. Data collection will include clinical examination findings, laboratory results, and relevant imaging, ensuring comprehensive identification and categorization of infections.

  30 days post-CABG

Study Arms (1)

CABG surgery

Procedure: CABG surgery

Interventions

CABG surgery PROCEDURE

CABG surgery

CABG surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study was conducted at Manmohan Cardio Thoracic Vascular and Transplant Center (MCVTC), a national tertiary referral center in Nepal performing over 20% of the country's cardiac surgeries. Using convenience sampling, adults (≥18 years) undergoing elective, isolated CABG were included. Patients having combined cardiac procedures, penicillin/cephalosporin allergy, refusal of consent, or loss to follow-up within 30 days were excluded.

You may qualify if:

• Adults aged 18 years or older
• Undergoing isolated coronary artery bypass graft (CABG) surgery
• Elective surgical cases

You may not qualify if:

• CABG performed in combination with other cardiac procedures (e.g., valve surgery, aortic aneurysm repair, congenital heart surgery)
• Known allergy to penicillin or cephalosporins
• Refusal to provide informed consent
• Loss to follow-up within 30 days after surgery

Sponsors & Collaborators

• Maharajgunj Medical Campus: lead

Study Sites (1)

Tribhuvan University Teaching Hospital, Kathmandu, Nepal

Kathmandu, Nepal

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 12, 2025
• First Posted: August 19, 2025
• Study Start: July 1, 2023
• Primary Completion: June 1, 2024
• Study Completion: June 1, 2024
• Last Updated: August 19, 2025

Record last verified: 2025-08

Locations

NE (1)