A Complex Intervention to Promote Appropriate Antibiotic Use Among Rural Residents Based on the Metaphor-Embedded Integrated Behavioral Model

NCT06967766 | Not Yet Recruiting

• 1 other identifier: ZGL202504-10
• Study Type: interventional
• Target: 1,500
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study aims to address the question of how to provide effective health education on health topics with high medical specialisation (e.g. bacterial drug resistance in this study), especially for rural or low-educated populations. In response to the high degree of correlation between irrational antimicrobial drug use behaviours, how to achieve the effectiveness of interventions on the complex health topic of rational use of antimicrobial drugs through synergistic interventions with multiple scenarios? In this study, the investigators used an experimental-like research design to conduct a full-scenario intervention involving antimicrobial drug acquisition, use, and disposal in a township-based approach, so as to reduce the prevalence of irrational antimicrobial drug use behaviours among rural residents, and to significantly improve the governance of antimicrobial drug use in rural areas. After six months of intervention, the following specific objectives were achieved:

1. 1.The incidence of self-treatment and use of antimicrobial drugs in the intervention group decreased by 30% compared with the control group;
2. 2.Rational use of antimicrobial drugs and awareness of bacterial drug resistance among rural residents in the intervention group increased by 50% compared with the control group;
3. 3.In the intervention group, the incidence of rural residents actively asking for antimicrobial drugs when seeking medical treatment, actively purchasing antimicrobial drugs without prescription at community pharmacies, stocking up on antimicrobial drugs at home, and improperly disposing of antimicrobial drugs decreased by 40%, 30%, 30%, and 50%, respectively, compared with that of the control group.

Conditions

Antimicrobial Drug Resistance

Keywords

health education; Metaphor

Outcome Measures

Primary Outcomes (1)

• antibiotic use

  Changes in antibiotic use rates among sick rural residents in the past month(self-treatment with antibiotics and antibiotics prescribed by doctors when seeking medical treatment)

  six months

Secondary Outcomes (5)

• knowledge

  six months

• Prevalence of unsolicited requests for antimicrobial drugs at medical appointments

  six months

• Prevalence of unsolicited purchase of antimicrobials without a prescription at a pharmacy

  six months

• Proportion of residents stocking antimicrobial drugs at home

  six months

• Incidence of unregulated disposal of antimicrobial drugs

  six months

Study Arms (2)

Metaphor-based health education

EXPERIMENTAL

In each intervention scenario, health education information is set to target key behaviors in the scenario. In the main scenarios for obtaining antibiotics, such as township health centers, village clinics, and community pharmacies, scenario-driven interventions are carried out for two key behaviors: patients actively asking for antibiotics (led by doctors in township health centers) and customers buying antibiotics without prescriptions (led by community pharmacy staff).

Behavioral: health education based on the Metaphor-Embedded Integrated Behavioral Model

Regular education

NO INTERVENTION

Interventions

health education based on the Metaphor-Embedded Integrated Behavioral Model BEHAVIORAL

In each intervention scenario, health education information is set to target key behaviors in the scenario. In the main scenarios for obtaining antibiotics, such as township health centers, village clinics, and community pharmacies, scenario-driven interventions are carried out for two key behaviors: patients actively asking for antibiotics (led by doctors in township health centers) and customers buying antibiotics without prescriptions (led by community pharmacy staff).

Metaphor-based health education

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Residents aged 18 years and over who have lived in the survey township for more than 6 months

You may not qualify if:

• Residents with mental illness, severe mental health problems, and those unable to complete the questionnaire

Sponsors & Collaborators

• Bo Yan: lead

MeSH Terms

Conditions

Health Education

Condition Hierarchy (Ancestors)

Adherence Interventions; Medication Adherence; Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: April 28, 2025
• First Posted: May 13, 2025
• Study Start: May 1, 2025
• Primary Completion: November 1, 2025
• Study Completion (Estimated): June 1, 2026
• Last Updated: May 13, 2025

Record last verified: 2025-05