End-tidal Carbon Dioxide as a Non-invasive Predictor for Changes in Cardiac Output in Non-cardiac Surgery

NCT06962748 | Completed

• 1 other identifier: FMASU R95/2025
• Study Type: interventional
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiac output (CO) is challenging to measure at the bedside. The traditional gold standard for measuring CO requires the insertion of a pulmonary artery catheter which is invasive, associated with a risk for serious complications \[3\],with no clinical benefits. The cerebral blood flow (CBF) is considered to be a proportion of total cardiac output (CO). It has been stated earlier that approximately 15% of resting CO is distributed to the brain. Therefore, the flow through the CCA might serve as a surrogate parameter for CO.

Conditions

Non Cardiac Surgery

Keywords

ETCO2- Cardiac output-Carotid blood flow

Outcome Measures

Primary Outcomes (1)

• correlation of ETCO2

  we assume that the change in the gradient of carbon dioxide release over a time in mechanically ventilated patients may be directly proportionate to the cardiac output and could reflect it. In the current study we will correlate the aforementioned hypothesis with the change in the cardiac output compared to the change in the carotid blood flow as revealed by the change in the cardiac output as measured by the transthoracic echocardiography.

  during operation

Study Arms (3)

ETCO2

ACTIVE COMPARATOR

The patients EtCO2 will be recorded and the average of the reading over a time interval of 30 minutes will be recorded and correlated to the cardiac output as measured by both the carotid blood flow and the TTE

Diagnostic Test: ETCO2

TTE CO

ACTIVE COMPARATOR

a transthoracic echocardiography will be done to measure the cardiac output

Diagnostic Test: TTE CO measurment

carotid blood flow

ACTIVE COMPARATOR

The patients' Cardiac output as measured before will be correlated with the carotid blood flow after scanning the carotid artery to exclude a significant lesion as measured by the following equation and the average of a three consecutive reading will be recorded

Diagnostic Test: cerebral blood flow measurment

Interventions

cerebral blood flow measurment DIAGNOSTIC_TEST

measuring CO using cerebral blood flow

carotid blood flow

TTE CO measurment DIAGNOSTIC_TEST

measuring CO using TTE

TTE CO

ETCO2 DIAGNOSTIC_TEST

measure the average ETCO2 over 30 minutes period

ETCO2

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The patients age will be ranged from 18-55 years,
• ASA physical status I-II,
• General surgeries not involving the head and neck
• Orthopedic surgeries involving the lower limb
• Patients in supine posture

You may not qualify if:

• Those with Respiratory disease including but not limited to Pneumonia, COPD, Restrictive lung disease and ARDS
• Those with anemia.
• Patients' refusal to participate in the study.
• Thoracic surgeries.
• Morbidly obese patients.
• Significant carotid artery disease.
• Surgeries of less than 2-hour duration.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Abbasiya, 12245, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 30, 2025
• First Posted: May 8, 2025
• Study Start: June 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: March 12, 2026

Record last verified: 2025-04

Locations

EG (1)