Myocardial Injury After Noncardiac Surgery (MINS) in Patients Undergoing Knee and Hip Arthroplasty

NCT07098468 | Completed

• 1 other identifier: MINS
• Study Type: observational
• Target: 323
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to determine the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing elective total knee or hip arthroplasty, and to identify the demographic, clinical, laboratory, and surgical risk factors that may contribute to its development.

Conditions

MYOCARD INFARCTUS; Non Cardiac Surgery; ARTHROPLASTY, REPLACEMENT; ANESTHESIA

Keywords

Myocardial injury, noncardiac surgery

Outcome Measures

Primary Outcomes (1)

• Ischemia-related myocardial damage after noncardiac surgery

  Diagnostic Biochemical Criteria for MINS: Myocardial Injury after Non-Cardiac Surgery (MINS) is defined when at least one of the following high-sensitivity cardiac troponin T (hs-cTnT) criteria is met: A postoperative hs-cTnT level of at least 20 ng/L combined with a minimum absolute increase of 5 ng/L from the preoperative value, or An absolute postoperative hs-cTnT concentration of ≥ 65 ng/L, regardless of baseline values. These threshold values are used to detect subclinical myocardial injury due to ischemia that occurs after surgery, even in the absence of ischemic symptoms or electrocardiographic changes. In this study, patients meeting at least one of the above criteria within 30 days postoperatively will be classified as having MINS.

  After surgery 30 days

Secondary Outcomes (1)

• Causes of myocardial damage due to ischemia following noncardiac surgery

  30 days

Study Arms (2)

Mins positivity

Patients with high sensitive troponin positivity after surgery

Mins Negative

Patients with negative high sensitive troponin after surgery

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study is planned to include 314 patients aged 45 and older undergoing elective hip or knee arthroplasty. Participants will be accepted for participation with physician approval and a voluntary consent form.

You may qualify if:

• Age over 45
• Elective total knee or hip replacement

You may not qualify if:

• Those undergoing cardiac surgery
• History of acute MI (\<30 days)
• Chronic elevation of troponin

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara City Hospital Bilkent

Ankara, 06800, Turkey (Türkiye)

Location

Study Officials

• Mehmet Şahap

  Sahap

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asist prof

Study Record Dates

• First Submitted: July 14, 2025
• First Posted: August 1, 2025
• Study Start: August 3, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: February 13, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)