Relation Between Lymphocyte-to-C-Reactive Protein Ratio and Coronary Artery Disease Complexity
1 other identifier
observational
600
0 countries
N/A
Brief Summary
Aim(s) of the Research :
- 1.To assess the relationship between the lymphocyte-to-CRP ratio and CAD complexity as assessed by Syntax score in both emergency (STEMI patients undergoing PPCI) and elective settings (patients undergoing scheduled CA plus PCI).
- 2.To test the relation between the LCR ratio and short-term major adverse cardiac events (MACE) within 6 months duration in patient undergoing primary PCI.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2025
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 12, 2025
CompletedFirst Posted
Study publicly available on registry
May 6, 2025
CompletedStudy Start
First participant enrolled
June 3, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 10, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 10, 2026
CompletedMay 6, 2025
April 1, 2025
6 months
April 12, 2025
April 27, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Relationship between Lymphocyte-to-CRP ratio and CAD complexity assessed by Syntax score
To assess the correlation between the lymphocyte-to-C-reactive protein (LCR) ratio and coronary artery disease (CAD) complexity as measured by Syntax score in STEMI and elective PCI patients.
At baseline during coronary angiography
Secondary Outcomes (1)
Association between Lymphocyte-to-CRP ratio and short-term major adverse cardiac events (MACE)
Within 3 months after PCI
Study Arms (2)
STEMI patients undergoing primary PCI
Description: Patients diagnosed with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) within 12 hours of symptom onset.
Elective PCI Patients
Description: Patients undergoing elective coronary angiography and PCI for stable coronary artery disease.
Interventions
No intervention administered. Standard care will be provided. Blood samples for lymphocyte count and CRP will be collected, and Syntax score will be calculated from angiography.
Eligibility Criteria
You may qualify if:
- Adults aged 18 to 80 years
- Diagnosed with STEMI undergoing primary PCI within 12 hours of symptom onset
- Patients undergoing elective PCI with documented coronary artery disease
- Provided written informed consent
You may not qualify if:
- Previous history of myocardial infarction, PCI, or coronary artery bypass grafting (CABG)
- Diagnosed autoimmune or chronic inflammatory disorders
- Active infection or malignancy at the time of presentation
- Severe renal impairment (eGFR \<30 mL/min/1.73 m²) or hepatic dysfunction
- Use of immunosuppressive therapy
- Diagnosis of acute or chronic leukemia within the past 6 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator, Department of cardiology, Assiut University
Study Record Dates
First Submitted
April 12, 2025
First Posted
May 6, 2025
Study Start
June 3, 2025
Primary Completion
December 10, 2025
Study Completion
April 10, 2026
Last Updated
May 6, 2025
Record last verified: 2025-04