NCT06942702

Brief Summary

The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

  1. 1.Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?
  2. 2.Does opioid consumption decrease in patients who underwent geniculate block?

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at P25-P50 for not_applicable

Timeline
7mo left

Started Dec 2025

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress38%
Dec 2025Dec 2026

First Submitted

Initial submission to the registry

April 17, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 24, 2025

Completed
8 months until next milestone

Study Start

First participant enrolled

December 20, 2025

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 20, 2026

Expected
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 20, 2026

Last Updated

December 23, 2025

Status Verified

December 1, 2025

Enrollment Period

10 months

First QC Date

April 17, 2025

Last Update Submit

December 16, 2025

Conditions

Total Knee AnthroplastyGenicular Nerves Block

Keywords

total knee arthroplastygenicular blockpostoperative pain

Outcome Measures

Primary Outcomes (2)

  • Visual Analog Scale Measure

    VAS scores are assessed at 0th, 24th and 48th hours post operatively VAS score consists of 0-10 in numbers, the bigger the number the worse the pain

    0-48 hours

  • opioid consumption

    Morphine consumption is assesed by PCA

    0-48 hours

Study Arms (2)

Genicular block group

ACTIVE COMPARATOR

this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Drug: Genicular blocks (bupivakain)Drug: Patient Control Analgesia (PCA) Morphine groupDrug: Paracetamol (acetaminophen) + Diclofenac Sodium

patients only given PCA-morfin postoperatively

ACTIVE COMPARATOR

this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed)

Drug: Patient Control Analgesia (PCA) Morphine groupDrug: Paracetamol (acetaminophen) + Diclofenac Sodium

Interventions

Genicular blocks (bupivakain)DRUG

Genicular block is a regional analgesic technique performed with USG

Genicular block group
Patient Control Analgesia (PCA) Morphine groupDRUG

this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)

Also known as: PCA-M
Genicular block grouppatients only given PCA-morfin postoperatively
Paracetamol (acetaminophen) + Diclofenac SodiumDRUG

All patients are given paracetamol (3x1000 mg) and diclofenac (if needed)

Genicular block grouppatients only given PCA-morfin postoperatively

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Scheduled for unilateral and primary total knee arthroplasty
  • Older than 18 years of age

You may not qualify if:

  • Younger than 18 years
  • Bilateral knee arthroplasty
  • Revision case of knee arthroplasty

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Wang T, Leng YF, Zhang Y, Kang YQ, Xue X, Zhang Y. [Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1130-5. Chinese.

    PMID: 21609599BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Passive Cutaneous AnaphylaxisAcetaminophenDiclofenac

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Intervention Hierarchy (Ancestors)

Skin TestsImmunologic TestsClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative TechniquesImmunologic TechniquesAntigen-Antibody ReactionsImmune System PhenomenaAcetanilidesAnilidesAmidesOrganic ChemicalsAniline CompoundsAminesPhenylacetatesAcids, CarbocyclicCarboxylic Acids

Study Officials

  • Mustafa Azizoglu, Associated Professor

    Mersin university Faculty of Medicine, Department of Anesthesiology and Reanimation

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mustafa Azizoglu, Associated Professor

CONTACT

+90 5325667061dryalamaoglu@hotmail.com

Mervenur Ozturk, Resident Doctor

CONTACT

+90 5525345189mervenurnurozturk@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associated Professor

Study Record Dates

First Submitted

April 17, 2025

First Posted

April 24, 2025

Study Start

December 20, 2025

Primary Completion (Estimated)

October 20, 2026

Study Completion (Estimated)

December 20, 2026

Last Updated

December 23, 2025

Record last verified: 2025-12