Neurocognitive Predictors of Health Risk Behaviors
1 other identifier
interventional
117
1 country
2
Brief Summary
This study proposes to extend the ongoing longitudinal study of health risk behaviors and obtain new data from former adolescents (followed previously from ages 13-22; Times 1-8) now from ages 23 to 28 (Times 9-11). The goal of this study is to examine the contribution of developing neurocognitive markers to substance use in young adulthood by following a well-characterized longitudinal sample.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2014
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 20, 2014
CompletedFirst Submitted
Initial submission to the registry
April 14, 2025
CompletedFirst Posted
Study publicly available on registry
April 23, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 31, 2029
February 12, 2026
February 1, 2026
15.4 years
April 14, 2025
February 10, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
substance use behaviors
Frequency (past year and past month use) of cigarette/tobacco, alcohol, cannabis, and other drug use will be asked.
Approximately every 18 months, 3 times across 5 years
Study Arms (1)
neurocognition
OTHERNeurocognitive tasks
Interventions
1. risk-processing: Participants choose between two choices across 72 trials of a forced choice decision-making neurocognitive task (Holt and Laury, 2002). Each trial included a high and low monetary outcome with an associated probability of occurring. Each choice option is shown as a pie with ten slices represented probabilities, in which each piece corresponded to ten percent. 2. cognitive control: A multi-source interference task (MSIT; Bush et al., 2003) is used in which participants are presented with three digits and asked to identify the digit different from the others. In the neutral condition, the target's identity is congruent with its relative position. In the interference condition, the target's identity does not match its relative position. There are a total of 96 neutral trials and 96 interference trials.
Eligibility Criteria
You may qualify if:
- \- Adolescents (now young adults) who participated in the original longitudinal project.
You may not qualify if:
- standard contraindications for magnetic resonance imaging at the study onset
- history of seizures/stroke
- a head injury with \> 10 min of unconsciousness or neurological sequelae
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Virginia Tech
Blacksburg, Virginia, 24061-0001, United States
Fralin Biomedical Research Institute at VTC
Roanoke, Virginia, 24016, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jungmeen Kim-Spoon, PhD
Virginia Polytechnic Institute and State University
- PRINCIPAL INVESTIGATOR
Brooks Casas, PhD
Virginia Polytechnic Institute and State University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
April 14, 2025
First Posted
April 23, 2025
Study Start
January 20, 2014
Primary Completion (Estimated)
May 31, 2029
Study Completion (Estimated)
May 31, 2029
Last Updated
February 12, 2026
Record last verified: 2026-02