Potential of Gayo Arabica Coffee Skin

NCT06940076 | Completed Phase 2

• 1 other identifier: 094/ETIK-RSUDZA/2024
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to assess the effectiveness of gayo arabica coffee skin extract cream in the prevention of skin aging

Conditions

Skin Aging

Outcome Measures

Primary Outcomes (3)

• Glogau scale examination

  the objective of this examination was to determine wrinkles. this parameter was measured before and after the study and then compared to assess the improvement

  8 weeks from the beginning of the cream used by the subject

• Skin analyzer examination

  the objective of this examination was to determine skin moisture, pigmentation. this parameter was measured before and after the study and then compared to assess the improvement

  8 weeks from the beginning of the cream used by the subject

• Corneometer examination

  the objective of this examination was to determine skin hydration. this parameter was measured before and after the study and then compared to assess the improvement

  8 weeks from the beginning of the cream used by the subject

Study Arms (1)

skin aging patients

EXPERIMENTAL

Drug: gayo arabica coffee skin extract cream

Interventions

gayo arabica coffee skin extract cream DRUG

Assessment of glagou scale, skin analyzer, corneometer, and tewameter was done before and after the treatment . The subject will receive directions on how to use the cream before the study starts. The cream was used 2 times daily (7.40 AM and 1.00 PM) for 8 weeks.

skin aging patients

Eligibility Criteria

• Age: 30 Years - 60 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Women.
• have skin aging condition aged 30-60 years.
• Willing to participate in research based on research protocols.
• Before the research begins, research subjects are willing to sign informed consent and participate in the research until completion according to the research provisions from initial examination, re-control, and treatment until completion).

You may not qualify if:

• History of allergy to one of the ingredients in the cream.
• have a skin disorder and are undergoing treatment for skin disease.
• Undergoing treatment and use of facial cream in the last 1 month.
• History of allergy to coffee.

Sponsors & Collaborators

• Wahyu Lestari: lead

Study Sites (1)

dr. Zainoel Abidin General Hospital

Banda Aceh, Special Region of Aceh, 23126, Indonesia

Location

Related Publications (10)

• Esquivel P, Jiménez VM. Functional Properties of Coffee and Coffee By-products. Food Res Int. 2012;5(3):1-9. doi:10.1016/j.foodres.2011.05.028

  BACKGROUND

• Murthy PS, Madhava Naidu M. Sustainable Management of Coffee Industry By-products and Value Addition - A review. Resour Conserv Recycl. Published online 2012:1-10. doi:10.1016/j.resconrec.2012.06.005

  BACKGROUND

• Sholichah E, Apriani R, Desnilasari D, Karim MA. Produk Samping Kulit Kopi Arabika dan Robusta Sebagai Sumber Polifenol Untuk Antioksidan dan Antibakteri. Balai Besar Ind Has Perkeb. Published online 2019:57-66.

  BACKGROUND

• Iriondo-DeHond A, Elizondo AS, Iriondo-DeHond M, Rios MB, Mufari R, Mendiola JA, Ibanez E, Castillo MDD. Assessment of Healthy and Harmful Maillard Reaction Products in a Novel Coffee Cascara Beverage: Melanoidins and Acrylamide. Foods. 2020 May 12;9(5):620. doi: 10.3390/foods9050620.

  PMID: 32408584 BACKGROUND

• Ameca GM, Cerrilla MEO, Córdoba PZ, Cruz AD, Hernández MS, Haro JH. Chemical Composition and Antioxidant Capacity of Coffee Pulp. Cienc e Agrotecnologia. 2018;4(3):307-313. doi:10.1590/1413-70542018423000818

  BACKGROUND

• Klingel T, Kremer JI, Gottstein V, Rajcic de Rezende T, Schwarz S, Lachenmeier DW. A Review of Coffee By-Products Including Leaf, Flower, Cherry, Husk, Silver Skin, and Spent Grounds as Novel Foods within the European Union. Foods. 2020 May 21;9(5):665. doi: 10.3390/foods9050665.

  PMID: 32455549 BACKGROUND

• Tuong W, Walker L, Sivamani RK. Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials. J Dermatolog Treat. 2015;26(4):381-8. doi: 10.3109/09546634.2014.991675. Epub 2014 Dec 30.

  PMID: 25424055 BACKGROUND

• Islam MT, Tabrez S, Jabir NR, Ali M, Kamal MA, da Silva Araujo L, De Oliveira Santos JV, Da Mata AMOF, De Aguiar RPS, de Carvalho Melo Cavalcante AA. An Insight into the Therapeutic Potential of Major Coffee Components. Curr Drug Metab. 2018;19(6):544-556. doi: 10.2174/1389200219666180302154551.

  PMID: 29512445 BACKGROUND

• Petruk G, Del Giudice R, Rigano MM, Monti DM. Antioxidants from Plants Protect against Skin Photoaging. Oxid Med Cell Longev. 2018 Aug 2;2018:1454936. doi: 10.1155/2018/1454936. eCollection 2018.

  PMID: 30174780 BACKGROUND

• Bosch R, Philips N, Suarez-Perez JA, Juarranz A, Devmurari A, Chalensouk-Khaosaat J, Gonzalez S. Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. Antioxidants (Basel). 2015 Mar 26;4(2):248-68. doi: 10.3390/antiox4020248.

  PMID: 26783703 BACKGROUND

Study Officials

• Wahyu Lestari, MD

  Department of dermatology, venereology, and aesthetic dr. Zainoel Abidin General Hospital Banda Aceh, Nanggroe Aceh Darussalam, Indonesia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 9, 2025
• First Posted: April 23, 2025
• Study Start: March 1, 2024
• Primary Completion: June 30, 2024
• Study Completion: November 30, 2024
• Last Updated: April 23, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)