Different Injection Speed on Local Anaesthetic Spread of ESPB

NCT06936904 | Recruiting DMC

• 1 other identifier: KY20250327-16
• Study Type: interventional
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this clinical trial is to investigate the effect of different injection speeds on the spread of local anesthetic during ultrasound-guided erector spinae plane block (ESPB) in patients undergoing CT-guided lung nodule localization. The primary question addressed is whether a high injection speed (30 ml delivered within 30 seconds) produces a different local anesthetic distribution compared with a lower injection speed (30 ml delivered within 180 seconds).

Conditions

Erector Spinae Plane Block

Outcome Measures

Primary Outcomes (1)

• Spread of local anesthetic into the paravertebral space

  Observation of local anesthetic spread into the paravertebral space with CT by a researcher who was blinded to group allocation

  30 minutes after completion of the ESPB block

Secondary Outcomes (8)

• Diffusion of local anesthetic into intercostal space

  30 minutes after completion of the block

• Diffusion of local anesthetic into the epidural space

  30 minutes after completion of the block

• Diffusion of local anesthetic into the neural foramina

  30 minutes after completion of the block

• Cephalocaudal spread of local anesthetic

  30 minutes after completion of the block

• Loss to Cold Sensation of Skin

  30 minutes after block

Study Arms (2)

Group C

OTHER

A total of 30 ml of the local anesthetic solution (0.375% ropivacaine, comprising 15 ml ropivacaine and 15 ml iodinated contrast) is injected. In the Group C, the injection is administered within 180 seconds.

Procedure: injection speed

Group S

EXPERIMENTAL

A total of 30 ml of the local anesthetic solution (0.375% ropivacaine, comprising 15 ml ropivacaine and 15 ml iodinated contrast) is injected. In the Group S, the injection is administered within 30 seconds.

Procedure: injection speed

Interventions

injection speed PROCEDURE

Patients undergoing CT-guided lung nodule localization were selected for the study, and ultrasound-guided erector spinae plane block was performed before surgery with different injection speed.

Group C; Group S

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients scheduled for CT-guided lung nodule localization under local anesthesia will be selected
• aged 18-80 years
• BMI 18-30 kg/m²
• ASA classification I-III

You may not qualify if:

• Allergy to the study drug or to local anesthetics
• History of opioid abuse
• Previous infection at the ESPB or PVB puncture site
• Peripheral neuropathy
• Dysfunction of blood coagulation

Sponsors & Collaborators

• Nanjing First Hospital, Nanjing Medical University: lead

Study Sites (1)

Nanjing First Hospital

Nanjing, Jiangsu, China

RECRUITING

Study Officials

• Tao Shan

  Nanjing First Hospital, Nanjing Medical University

  STUDY CHAIR

Central Study Contacts

Tao Shan

CONTACT

+8618852095135; shantao2021@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending physician

Study Record Dates

• First Submitted: April 13, 2025
• First Posted: April 20, 2025
• Study Start: April 21, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: May 22, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)