Role of Cerebroplacental Ratio Discordance at 16-20 Weeks in Predicting Monochorionic Twin Pregnancies' Specific Complications

NCT06935422 | Recruiting

• 1 other identifier: Monochorionic twins
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the predictive value of CPR discordance at 16-20 weeks in MCDA twin pregnancies in predicting monochorionic-specific complications such as TTTS, TAPS, sFGR and IUFD of one or both fetuses

Conditions

Monochorionic Twins; Cerebroplacental Ratio

Keywords

Monochorionic twins

Outcome Measures

Primary Outcomes (1)

• Development of monochorionic specific complications

  Monochorionic specific complications include twin to twin transfusion syndrome, twin anemia polycythemia sequence and selective fetal growth restriction

  From 16-20 weeks of gestation till delivery.

Secondary Outcomes (1)

• Occurrence of intrauterine fetal death or perinatal mortality of one or both fetuses

  From 16-20 weeks of gestation till 7th day of life

Interventions

Ultrasound DEVICE

Measuring cerebroplacental ratio discordance in monochorionic twins at 16-20 Weeks of gestation

Eligibility Criteria

• Sex: female
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Monochorionic diamniotic twin pregnancies with discordant cerebroplacental ratio at 16-20 weeks of gestation presenting to Ain Shams University Maternity Hospital for antenatal care.

You may qualify if:

• Aged 18 years or more and able to consent.
• Monochorionic Diamniotic twin pregnancy.
• Discordant inter-twin cerebroplacental ratio at 16-20 weeks of gestation.

You may not qualify if:

• Fetal structural malformations or chromosomal abnormalities in any of the twins as detected by anomaly scan antenatally or neonatal examination postnatally (chromosomal abnormalities and some congenital malformations can interfere with normal fetal growth).
• Identified infectious etiologies detected during immediate postnatal examination or during pregnancy (fetal infections can cause FGR ,usually symmetric type particularly if they occur in early gestation).
• Referral after development of Twin to twin transfusion syndrome, twin anemia polycythemia sequence or selective fetal growth restriction.
• Single fetal demise at the time enrollment in the study.
• Conjoint twins.

Sponsors & Collaborators

• Ain Shams Maternity Hospital: lead

Study Sites (1)

Ain shams maternity hospital

Cairo, Egypt

RECRUITING

Related Publications (3)

• Jain A, Acharya V, Shettikeri A, Sahana R, Radhakrishnan P. Intertwin discordance in MCA-PI and CPR in the prediction of TTTS progression. 19th world congress in fetal medicine. Ultrasound Obstet Gynecol. 2022;1(1):5-9.

  BACKGROUND

• Conde-Agudelo A, Villar J, Kennedy SH, Papageorghiou AT. Predictive accuracy of cerebroplacental ratio for adverse perinatal and neurodevelopmental outcomes in suspected fetal growth restriction: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018 Oct;52(4):430-441. doi: 10.1002/uog.19117. Epub 2018 Sep 5.

  PMID: 29920817 BACKGROUND

• Albu AR, Anca AF, Horhoianu VV, Horhoianu IA. Predictive factors for intrauterine growth restriction. J Med Life. 2014 Jun 15;7(2):165-71. Epub 2014 Jun 25.

  PMID: 25408721 BACKGROUND

MeSH Terms

Interventions

Ultrasonography

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Heba Abdelbaset Abd elkawy, Assistant professor

  Ain Shams Maternity Hospital

  STUDY CHAIR

• Haitham Mohsen Elsabaa, Professor

  Ain Shams Maternity Hospital

  STUDY CHAIR

• Amr Fathy Abd elkareem, Professor

  Ain Shams Maternity Hospital

  STUDY DIRECTOR

Central Study Contacts

Muhammed Ali Hassan, Assistant lecturer

CONTACT

+201020256117; muhammedali20191@yahoo.com

Mohamed Sameh Elswaify, Lecturer

CONTACT

+201285003060

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: March 12, 2025
• First Posted: April 20, 2025
• Study Start: March 1, 2025
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 15, 2026
• Last Updated: September 5, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: From 2025 till 2028
• Access Criteria: Any researcher, physician or university lecturer Access for full study content

Locations

EG (1)